G
Guenter Haemmerle
Researcher at University of Graz
Publications - 90
Citations - 13688
Guenter Haemmerle is an academic researcher from University of Graz. The author has contributed to research in topics: Adipose triglyceride lipase & Adipose tissue. The author has an hindex of 44, co-authored 86 publications receiving 11893 citations. Previous affiliations of Guenter Haemmerle include Joanneum Research.
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Journal ArticleDOI
Fat Mobilization in Adipose Tissue Is Promoted by Adipose Triglyceride Lipase
Robert Zimmermann,Juliane G. Strauss,Guenter Haemmerle,Gabriele Schoiswohl,Ruth Birner-Gruenberger,Monika Riederer,Achim Lass,Georg Neuberger,Frank Eisenhaber,Albin Hermetter,Rudolf Zechner +10 more
TL;DR: It is reported that a second enzyme, adipose triglyceride lipase (ATGL), catalyzes the initial step in triglyceride hydrolysis, and it is interesting that ATGL contains a “patatin domain” common to plant acyl-hydrolases.
Journal ArticleDOI
Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase
Guenter Haemmerle,Achim Lass,Robert Zimmermann,Gregor Gorkiewicz,Carola W. Meyer,Jan Rozman,Gerhard Heldmaier,Robert Maier,Christian Theussl,Sandra Eder,Dagmar Kratky,Erwin F. Wagner,Martin Klingenspor,Gerald Hoefler,Rudolf Zechner +14 more
TL;DR: The results indicate that ATGL is rate limiting in the catabolism of cellular fat depots and plays an important role in energy homeostasis.
Journal ArticleDOI
FAT SIGNALS - Lipases and Lipolysis in Lipid Metabolism and Signaling
Rudolf Zechner,Robert Zimmermann,Thomas O. Eichmann,Sepp D. Kohlwein,Guenter Haemmerle,Achim Lass,Frank Madeo +6 more
TL;DR: New findings that lipolytic products and intermediates participate in cellular signaling processes and that “lipolytic signaling” is particularly important in many nonadipose tissues unveil a previously underappreciated aspect of lipolysis, which may be relevant for human disease.
Journal ArticleDOI
Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome.
Achim Lass,Robert Zimmermann,Guenter Haemmerle,Monika Riederer,Gabriele Schoiswohl,Martina Schweiger,Petra C. Kienesberger,Juliane G. Strauss,Gregor Gorkiewicz,Rudolf Zechner +9 more
TL;DR: Exercise of functional CGI-58 in CDS fibroblasts restores lipolysis and reverses the abnormal TG accumulation typical for CDS, establishing an important biochemical function for CGI- 58 in the lipolytic degradation of fat.
Journal ArticleDOI
Cardioprotection and lifespan extension by the natural polyamine spermidine
Tobias Eisenberg,Mahmoud Abdellatif,Sabrina Schroeder,Uwe Primessnig,Uwe Primessnig,Slaven Stekovic,Tobias Pendl,Alexandra Harger,Alexandra Harger,Julia Schipke,Andreas Zimmermann,Albrecht Schmidt,Mingming Tong,Christoph Ruckenstuhl,Christopher Dammbrueck,Angelina S. Gross,Viktoria Herbst,Christoph Magnes,Gert Trausinger,Sophie H. Narath,Andreas Meinitzer,Zehan Hu,Zehan Hu,Alexander H. Kirsch,Kathrin Eller,Didac Carmona-Gutierrez,Sabrina Büttner,Sabrina Büttner,Federico Pietrocola,Oskar Knittelfelder,Emilie Schrepfer,Patrick Rockenfeller,Patrick Rockenfeller,Corinna Simonini,Alexandros Rahn,Marion Horsch,Kristin Moreth,Johannes Beckers,Helmut Fuchs,Valerie Gailus-Durner,Frauke Neff,Dirk Janik,Birgit Rathkolb,Jan Rozman,Martin Hrabé de Angelis,Tarek Moustafa,Tarek Moustafa,Guenter Haemmerle,Manuel Mayr,Peter Willeit,Peter Willeit,Marion von Frieling-Salewsky,Burkert Pieske,Burkert Pieske,Luca Scorrano,Thomas R. Pieber,Thomas R. Pieber,Raimund Pechlaner,Johann Willeit,Stephan J. Sigrist,Stephan J. Sigrist,Wolfgang A. Linke,Christian Mühlfeld,Junichi Sadoshima,Joern Dengjel,Joern Dengjel,Stefan Kiechl,Guido Kroemer,Simon Sedej,Frank Madeo +69 more
TL;DR: It is shown that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice, and suggests a new and feasible strategy for protection against cardiovascular disease.