P
Petra C. Kienesberger
Researcher at Dalhousie University
Publications - 56
Citations - 4112
Petra C. Kienesberger is an academic researcher from Dalhousie University. The author has contributed to research in topics: Adipose triglyceride lipase & Adipose tissue. The author has an hindex of 27, co-authored 55 publications receiving 3521 citations. Previous affiliations of Petra C. Kienesberger include University of Graz & University of Alberta.
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Journal ArticleDOI
Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome.
Achim Lass,Robert Zimmermann,Guenter Haemmerle,Monika Riederer,Gabriele Schoiswohl,Martina Schweiger,Petra C. Kienesberger,Juliane G. Strauss,Gregor Gorkiewicz,Rudolf Zechner +9 more
TL;DR: Exercise of functional CGI-58 in CDS fibroblasts restores lipolysis and reverses the abnormal TG accumulation typical for CDS, establishing an important biochemical function for CGI- 58 in the lipolytic degradation of fat.
Journal ArticleDOI
ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1
Guenter Haemmerle,Tarek Moustafa,Gerald Woelkart,Sabrina Büttner,Albrecht Schmidt,Tineke van de Weijer,Matthijs K. C. Hesselink,Doris Jaeger,Petra C. Kienesberger,Kathrin A. Zierler,Renate Schreiber,Thomas O. Eichmann,Dagmar Kolb,Petra Kotzbeck,Martina Schweiger,Manju Kumari,Sandra Eder,Gabriele Schoiswohl,Nuttaporn Wongsiriroj,Nina M. Pollak,Franz P.W. Radner,Karina Preiss-Landl,Thomas Kolbe,Thomas Rülicke,Burkert Pieske,Michael Trauner,Achim Lass,Robert Zimmermann,Gerald Hoefler,Saverio Cinti,Erin E. Kershaw,Patrick Schrauwen,Frank Madeo,Bernd Mayer,Rudolf Zechner +34 more
TL;DR: Reconstituting normal PPAR target gene expression by pharmacological treatment of Atgl-deficient mice with PPAR-α agonists completely reverses the mitochondrial defects, restores normal heart function and prevents premature death.
Journal ArticleDOI
Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores
TL;DR: The structure, function, and regulation of lipolytic enzymes with a special emphasis on ATGL are focused on, which create the "lipolysome," a complex metabolic network that contributes to the control of lipid and energy homeostasis.
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Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions.
TL;DR: The human genome expresses nine patatin-like phospholipase domain containing proteins (PNPLA1-9) as mentioned in this paper, which share a protein domain discovered initially in patatin, the most abundant protein of the potato tuber.
Journal ArticleDOI
Lipid metabolism and signaling in cardiac lipotoxicity.
TL;DR: This review summarizes the current understanding of lipid uptake, metabolism and signaling pathways that have been implicated in the development of lipotoxic cardiomyopathy under conditions including obesity, diabetes, aging, and myocardial ischemia-reperfusion.