J
Julie E. Norville
Researcher at Harvard University
Publications - 15
Citations - 12237
Julie E. Norville is an academic researcher from Harvard University. The author has contributed to research in topics: Genome & Cas9. The author has an hindex of 10, co-authored 15 publications receiving 10965 citations. Previous affiliations of Julie E. Norville include Massachusetts Institute of Technology & Vassar College.
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Journal ArticleDOI
RNA-Guided Human Genome Engineering via Cas9
Prashant Mali,Luhan Yang,Kevin M. Esvelt,John Aach,Marc Güell,James E. DiCarlo,Julie E. Norville,George M. Church,George M. Church +8 more
TL;DR: The type II bacterial CRISPR system is engineer to function with custom guide RNA (gRNA) in human cells to establish an RNA-guided editing tool for facile, robust, and multiplexable human genome engineering.
Journal ArticleDOI
Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems
TL;DR: The use of type II bacterial CRISPR-Cas system in Saccharomyces cerevisiae for genome engineering provides foundations for a simple and powerful genome engineering tool for site-specific mutagenesis and allelic replacement in yeast.
Journal ArticleDOI
Multiplex and homologous recombination–mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9
Jian-Feng Li,Julie E. Norville,John Aach,Matthew McCormack,Dandan Zhang,Jenifer Bush,George M. Church,Jen Sheen +7 more
TL;DR: Multiplex and homologous recombination–mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9 is described.
Journal ArticleDOI
Integration of Photosynthetic Protein Molecular Complexes in Solid-State Electronic Devices
R. Das,Patrick Kiley,Michael Segal,Julie E. Norville,A. Amy Yu,Leyu Wang,Scott A. Trammell,L. Evan Reddick,Rajay Kumar,Francesco Stellacci,Nikolai Lebedev,Joel M. Schnur,Barry D. Bruce,Shuguang Zhang,Marc A. Baldo +14 more
TL;DR: In this paper, the integration of electrically active photosynthetic protein−molecular complexes in solid-state devices was demonstrated, achieving photodetectors and photovoltaic cells with internal quantum efficiencies of approximately 12%.
Journal ArticleDOI
Biocontainment of genetically modified organisms by synthetic protein design
Daniel J. Mandell,Marc J. Lajoie,Michael T. Mee,Ryo Takeuchi,Gleb Kuznetsov,Julie E. Norville,Christopher J. Gregg,Barry L. Stoddard,George M. Church +8 more
TL;DR: This work computationally redesign essential enzymes in the first organism possessing an altered genetic code to confer metabolic dependence on non-standard amino acids for survival, providing a foundation for safer GMOs that are isolated from natural ecosystems by a reliance on synthetic metabolites.