J
Julie E. Ralton
Researcher at University of Melbourne
Publications - 30
Citations - 1046
Julie E. Ralton is an academic researcher from University of Melbourne. The author has contributed to research in topics: Leishmania mexicana & Mannose. The author has an hindex of 19, co-authored 30 publications receiving 988 citations. Previous affiliations of Julie E. Ralton include Monash University & University of Dundee.
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Journal ArticleDOI
Delineation of three pathways of glycosylphosphatidylinositol biosynthesis in Leishmania mexicana. Precursors from different pathways are assembled on distinct pools of phosphatidylinositol and undergo fatty acid remodeling.
TL;DR: This study has identified putative precursors for the protein and lipophosphoglycan anchors and delineated the complete pathway for GIPL biosynthesis in Leishmania mexicana promastigotes and suggests that the compartmentalization of different GPI pathways may be important in regulating the species and stage-specific expression ofDifferent GPI structures in these parasites.
Journal ArticleDOI
Evidence That Intracellular β1-2 Mannan Is a Virulence Factor in Leishmania Parasites
Julie E. Ralton,Thomas Naderer,Helena L. Piraino,Tanya Bashtannyk,Judy M. Callaghan,Malcolm J. McConville +5 more
TL;DR: Evidence is provided that a novel class of intracellular β1-2 mannan oligosaccharides is important for parasite survival in host macrophages and for parasite differentiation and survival in Macrophages.
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Evidence that free GPI glycolipids are essential for growth of Leishmania mexicana.
TL;DR: Evidence presented in this and previous studies indicates that neither GPI‐anchored glycoproteins nor lipophosphoglycan are required for growth of cultured parasites, it is possible that the abundant and functionally uncharacterized free GPIs are essential membrane components.
Journal ArticleDOI
Glycosyl-phosphatidylinositol molecules of the parasite and the host.
Michael A. J. Ferguson,John S. Brimacombe,Sylvain Cottaz,Robert A. Field,L.S. Guther,Steven W. Homans,Malcolm J. McConville,Angela Mehlert,Kenneth G. Milne,Julie E. Ralton,Y.A. Roy,Pascal Schneider,Nicole Zitzmann +12 more
TL;DR: The highly elevated levels and specialised nature of GPI metabolism in the kinetoplastid parasites suggest that the GPI biosynthetic pathways might be good targets for the development of chemotherapeutic agents.
Journal ArticleDOI
Central carbon metabolism of Leishmania parasites.
Eleanor C Saunders,David P De Souza,Thomas Naderer,Marikje F Sernee,Julie E. Ralton,Maria A. Doyle,James I. MacRae,Jenny L. Chambers,Joanne Heng,Amsha Nahid,Vladimir A Likic,Malcolm J. McConville +11 more
TL;DR: Recent advances in understanding of Leishmania central carbon metabolism are summarized, focusing on pathways of carbon utilization that are required for growth and pathogenesis in the mammalian host.