J
Julien Guglielmini
Researcher at Pasteur Institute
Publications - 42
Citations - 2682
Julien Guglielmini is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Multilocus sequence typing & Genome. The author has an hindex of 17, co-authored 39 publications receiving 2107 citations. Previous affiliations of Julien Guglielmini include French Institute of Health and Medical Research & University of Paris.
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Journal ArticleDOI
Diversity of bacterial type II toxin–antitoxin systems: a comprehensive search and functional analysis of novel families
Raphaël Leplae,Damien Geeraerts,Régis Hallez,Julien Guglielmini,Pierre-Alexandre Drèze,Laurence Van Melderen +5 more
TL;DR: It is proposed that due to their addictive properties, TA systems are likely to be maintained in chromosomes even though they do not necessarily confer an advantage to their bacterial hosts.
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The Repertoire of ICE in Prokaryotes Underscores the Unity, Diversity, and Ubiquity of Conjugation
Julien Guglielmini,Leonor Quintais,Leonor Quintais,Maria Pilar Garcillán-Barcia,Fernando de la Cruz,Eduardo P. C. Rocha,Eduardo P. C. Rocha +6 more
TL;DR: According to the present results, ICEs are the most abundant conjugative elements in practically all prokaryotic clades and might be far more frequently domesticated into non-conjugative protein transport systems than previously thought.
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Identification of protein secretion systems in bacterial genomes
Sophie S. Abby,Jean Cury,Jean Cury,Julien Guglielmini,Julien Guglielmini,Bertrand Néron,Marie Touchon,Marie Touchon,Eduardo P. C. Rocha,Eduardo P. C. Rocha +9 more
TL;DR: Online and standalone computational tools to accurately predict protein secretion systems and related appendages in bacteria with LPS-containing outer membranes are built and can be fully customized, which should facilitate the identification of novel systems.
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A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development
Martina L. Sanderson-Smith,David M. P. De Oliveira,Julien Guglielmini,David J. McMillan,Therese Vu,Jessica K. Holien,Anna Henningham,Andrew C Steer,Debra E. Bessen,James B. Dale,Nigel Curtis,Bernard Beall,Mark J. Walker,Michael W. Parker,Jonathan R. Carapetis,Laurence Van Melderen,Kadaba S. Sriprakash,Pierre R. Smeesters +17 more
TL;DR: A functional classification based on 48 emm-clusters containing closely related M proteins that share binding and structural properties is proposed and will facilitate the design of future studies of M protein function, streptococcal virulence, epidemiological surveillance, and vaccine development.
Journal ArticleDOI
Evolution of conjugation and type IV secretion systems
TL;DR: In this article, the authors analyzed the phylogeny of key conjugation proteins to infer the evolutionary history of conjugations and type IV secretion systems (T4SS) and showed that single-stranded DNA (ssDNA) and double-strand DNA (dsDNA), while both based on a key AAA + ATPase, diverged before the last common ancestor of bacteria.