J
Julio C. Morote-Garcia
Researcher at University of Tübingen
Publications - 13
Citations - 1918
Julio C. Morote-Garcia is an academic researcher from University of Tübingen. The author has contributed to research in topics: Adenosine & Hypoxia (medical). The author has an hindex of 12, co-authored 13 publications receiving 1766 citations. Previous affiliations of Julio C. Morote-Garcia include Brigham and Women's Hospital.
Papers
More filters
Journal ArticleDOI
Crucial Role for Ecto-5′-Nucleotidase (CD73) in Vascular Leakage during Hypoxia
Linda F. Thompson,Holger K. Eltzschig,Juan C. Ibla,Juan C. Ibla,C. Justin Van De Wiele,Regina Resta,Julio C. Morote-Garcia,Sean P. Colgan +7 more
TL;DR: Vascular leakage secondary to hypoxia was reversed in part by adenosine receptor agonists or reconstitution with soluble 5′-nucleotidase, and CD73 is identified as a critical mediator of vascular leakage in vivo.
Journal ArticleDOI
Hypoxia-inducible factor-dependent induction of netrin-1 dampens inflammation caused by hypoxia.
Peter Rosenberger,Jan M. Schwab,Valbona Mirakaj,Eva Masekowsky,Alice Mager,Julio C. Morote-Garcia,Klaus Unertl,Holger K. Eltzschig,Holger K. Eltzschig +8 more
TL;DR: It is demonstrated that HIF-1α-dependent induction of netrin-1 attenuates hypoxia-elicited inflammation at mucosal surfaces.
Journal ArticleDOI
HIF-1-dependent repression of adenosine kinase attenuates hypoxia-induced vascular leak.
Julio C. Morote-Garcia,Peter Rosenberger,Johannes Kuhlicke,Holger K. Eltzschig,Holger K. Eltzschig +4 more
TL;DR: In this article, the authors studied the contribution of adenosine kinase (AK) to vascular adaptation to hypoxia and found that AK inhibition with 5'-iodotubericidin (1 mg/kg) significantly attenuated hypoxiosis-induced vascular leakage in multiple organs and reduced hypoxiasassociated increases in lung water.
Journal ArticleDOI
Hypoxia inducible factor (HIF)-1 coordinates induction of Toll-like receptors TLR2 and TLR6 during hypoxia.
Johannes Kuhlicke,Julia S. Frick,Julio C. Morote-Garcia,Peter Rosenberger,Holger K. Eltzschig,Holger K. Eltzschig +5 more
TL;DR: These studies reveal coordinated induction of TLR2 and TLR6 during hypoxia and suggest tissue hypoxIA in transcriptional adaptation of innate immune responses during acute infection or inflammation.
Journal Article
HIF-1-dependent repression of adenosine kinase attenuates hypoxia-induced vascular leak. Commentary
Michail V. Sitkovsky,Julio C. Morote-Garcia,Peter Rosenberger,Johannes Kuhlicke,Holger K. Eitzschig +4 more
TL;DR: A critical role of AK is revealed in modulating vascular adenosine responses and pharmacologic inhibitors of AK are suggested in the treatment of conditions associated with hypoxia-induced vascular leakage (eg, sepsis or acute lung injury).