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Sean P. Colgan
Researcher at Anschutz Medical Campus
Publications - 323
Citations - 31494
Sean P. Colgan is an academic researcher from Anschutz Medical Campus. The author has contributed to research in topics: Inflammation & Intestinal mucosa. The author has an hindex of 89, co-authored 301 publications receiving 27723 citations. Previous affiliations of Sean P. Colgan include Veterans Health Administration & Harvard University.
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Journal ArticleDOI
Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals.
Charles N. Serhan,Song Hong,Karsten Gronert,Sean P. Colgan,Pallavi R. Devchand,Gudrun E. Mirick,Rose-Laure Moussignac +6 more
TL;DR: It is reported that lipidomic analysis of exudates obtained in the resolution phase from mice treated with ASA and docosahexaenoic acid produce a novel family of bioactive 17R-hydroxy-containing di- and tri-Hydroxy-docosanoids termed resolvins.
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Novel Functional Sets of Lipid-Derived Mediators with Antiinflammatory Actions Generated from Omega-3 Fatty Acids via Cyclooxygenase 2–Nonsteroidal Antiinflammatory Drugs and Transcellular Processing
TL;DR: It is reported that inflammatory exudates from mice treated with ω-3 polyunsaturated fatty acid and aspirin (ASA) generate a novel array of bioactive lipid signals, which provides a novel mechanism for the therapeutic benefits ofπ-3 dietary supplementation, which may be important in inflammation, neoplasia, and vascular diseases.
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Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function
Caleb J. Kelly,Leon Zheng,Eric L. Campbell,Bejan Saeedi,Carsten C. Scholz,Amanda Bayless,Kelly Wilson,Louise E. Glover,Douglas J. Kominsky,Aaron Magnuson,Tiffany L. Weir,Stefan F. Ehrentraut,Stefan F. Ehrentraut,Christina Pickel,Kristine A. Kuhn,Jordi M. Lanis,Vu Nguyen,Cormac T. Taylor,Sean P. Colgan +18 more
TL;DR: A mechanism where host-microbe interactions augment barrier function in the distal gut is highlighted, where the influences of butyrate are lost in cells lacking HIF, thus linkingbutyrate metabolism to stabilized HIF and barrier function.
Journal Article
Hypoxia-inducible Factor-1-dependent Regulation of the Multidrug Resistance (MDR1) Gene
Katrina M. Comerford,Timothy J. Wallace,Jörn Karhausen,Nancy A. Louis,Michael Christopher Montalto,Sean P. Colgan +5 more
TL;DR: Hypoxia-elicited MDR1 gene induction and increased P-glycoprotein expression in nontransformed, primary cultures of human microvascular endothelial cells, and analysis of multicellular spheroids subjected to hypoxia revealed increased resistance to doxorubicin are confirmed.
Journal ArticleDOI
Ecto-5′-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia
Kristin Synnestvedt,Glenn T. Furuta,Katrina M. Comerford,Nancy A. Louis,Jörn Karhausen,Holger K. Eltzschig,Karl R. Hansen,Linda F. Thompson,Sean P. Colgan +8 more
TL;DR: The results identify an HIF-1-dependent regulatory pathway for CD73 and indicate the likelihood that CD39/CD73 protects the epithelial barrier during hypoxia.