Julius Fredens

TL;DR: The number of codons used to encode the canonical amino acids can be reduced, through the genome-wide substitution of target codons by defined synonyms, through a high-fidelity convergent total synthesis.

TL;DR: This work endow E. coli with a system for efficient, programmable replacement of genomic DNA with long synthetic DNA, through the in vivo excision of double-stranded DNA from an episomal replicon by CRISPR/Cas9, coupled to lambda-red-mediated recombination and simultaneous positive and negative selection.

TL;DR: In this article, the authors showed that removing cellular transfer RNAs (tRNAs) might create a genetic firewall to viral infection and enable sense codon reassignment, but it has been impossible to test these hypotheses.

TL;DR: Using heavy isotope–labeled worms and quantitative proteomics methods, several proteins that are regulated in response to loss or RNAi-mediated knockdown of the nuclear hormone receptor 49 in C. elegans are identified.

TL;DR: In Caenorhabditis elegans, the SAX-7/L1CAM cell adhesion molecule engages in distinct molecular mechanisms to mediate extensions of PVD 1° dendrites and maintain the ALA-PVD axon-dendritic fascicle, respectively, showing that axons can serve as critical scaffolds to pattern and maintain dendrite formation through contact-dependent but activity-independent mechanisms.