J
Jun Gong
Researcher at City of Hope National Medical Center
Publications - Â 90
Citations - Â 1968
Jun Gong is an academic researcher from City of Hope National Medical Center. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 15, co-authored 34 publications receiving 1352 citations. Previous affiliations of Jun Gong include University of California, Los Angeles.
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Development of PD-1 and PD-L1 inhibitors as a form of cancer immunotherapy: a comprehensive review of registration trials and future considerations.
TL;DR: Predictive biomarkers, mechanisms of resistance, hyperprogressors, treatment duration and treatment beyond progression, immune-related toxicities, and clinical trial design are key concepts in need of further consideration to optimize the anticancer potential of this class of immunotherapy.
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Response to PD-1 Blockade in Microsatellite Stable Metastatic Colorectal Cancer Harboring a POLE Mutation
TL;DR: This report presents the first case in the literature describing a clinical response to pembrolizumab in an 81-year-old man with treatment-refractory mCRC characterized by an MSS phenotype and POLE mutation identified on genomic profiling by next-generation sequencing.
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Adaptive Unfolded Protein Response Attenuates Alcohol-Induced Pancreatic Damage
Aurelia Lugea,David Tischler,Janie Nguyen,Jun Gong,Ilya Gukovsky,Samuel W. French,Fred S. Gorelick,Stephen J. Pandol +7 more
TL;DR: The role of X-box binding protein 1 (XBP1), a UPR regulator, in prevention of alcohol-induced ER stress in the exocrine pancreas is investigated and a defective UPR due to XBP1 deficiency results in ER dysfunction and acinar cell pathology.
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Radiation therapy and PD-1/PD-L1 blockade: the clinical development of an evolving anticancer combination
TL;DR: This review highlights the preclinical and clinical development of combined RT and PD-1/PD-L1 blockade and discusses important points of consideration in clinical trial design for this promising combination.
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Metastasis in renal cell carcinoma: Biology and implications for therapy
TL;DR: The underlying biology of RCC and plausible mechanisms of metastasis are focused on and evolving strategies to combat metastasis through adjuvant therapy are outlined.