J
Jun Hyoung Lee
Researcher at KAIST
Publications - 28
Citations - 1122
Jun Hyoung Lee is an academic researcher from KAIST. The author has contributed to research in topics: Escherichia coli & Genome. The author has an hindex of 13, co-authored 28 publications receiving 949 citations.
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Journal ArticleDOI
Phenotypic engineering by reprogramming gene transcription using novel artificial transcription factors in Escherichia coli
Ju Young Lee,Bong Hyun Sung,Byung Jo Yu,Jun Hyoung Lee,Sang Hee Lee,Mi Sun Kim,Michael D. Koob,Sun Chang Kim +7 more
TL;DR: Novel ATFs capable of reprogramming innate gene expression circuits in Escherichia coli induced various phenotypic changes in E. coli and selected for industrially important traits, such as resistance to heat shock, osmotic pressure and cold shock, indicating that novel ATFs are powerful tools for the phenotyping engineering of microorganisms and can facilitate microbial functional genomic studies.
Journal ArticleDOI
Minimization of the Escherichia coli genome using a Tn5-targeted Cre/loxP excision system
Byung Jo Yu,Bong Hyun Sung,Michael D. Koob,Choong Hoon Lee,Jun Hyoung Lee,Won Sik Lee,Mi Sun Kim,Sun Chang Kim +7 more
TL;DR: A genome-engineering tool for determining essential genes and minimizing bacterial genomes is developed and two large pools of independent transposon mutants in Escherichia coli are made using modified Tn5 transposons with two different selection markers.
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Two Ginseng UDP-Glycosyltransferases Synthesize Ginsenoside Rg3 and Rd
Suk-Chae Jung,Woohyun Kim,Sung Chul Park,Jinkil Jeong,Myung Keun Park,Soohwan Lim,Yeon Lee,Wan-Taek Im,Jun Hyoung Lee,Giltsu Choi,Sun Chang Kim +10 more
TL;DR: This work sequenced and assembled the ginseng transcriptome de novo and characterized two UDP-glycosyltransferases (PgUGTs), indicating that these two UGTs are key enzymes for the synthesis of ginsenosides and provide a method for producing specific ginsene biosynthesis through yeast fermentation.
Journal ArticleDOI
Metabolic engineering of a reduced-genome strain of Escherichia coli for L-threonine production.
Jun Hyoung Lee,Bong Hyun Sung,Mi Sun Kim,Frederick R. Blattner,Byoung Hoon Yoon,Jung Hoe Kim,Sun Chang Kim +6 more
TL;DR: This result demonstrates that the elimination of genes unnecessary for cell growth can increase the productivity of an industrial strain, most likely by reducing the metabolic burden and improving the metabolic efficiency of cells.
Journal ArticleDOI
Adaptive laboratory evolution of a genome-reduced Escherichia coli
Donghui Choe,Jun Hyoung Lee,Minseob Yoo,Soonkyu Hwang,Bong Hyun Sung,Suhyung Cho,Bernhard O. Palsson,Sun Chang Kim,Byung-Kwan Cho +8 more
TL;DR: Adaptive laboratory evolution is deployed to re-optimise growth performance and show transcriptome and translatome-wide remodeling of the organism that orchestrate metabolism and growth.