This study describes the development, optimization, and evaluation of a novel  composite  imprinted  polymer, on  the  basis  of  magnetic  halloysite   nanotubes  (MHNTs-MIPs) using “Quality by Design (QbD)” approach combining computer simulation and response surface methodology. Norfloxacin, methacrylic acid, and ethylene glycol dimethacrylate were used as template, functional monomer and cross-linker, respectively. As a comparison, two MHNTs-MIPs have been prepared with the most suitable functional monomer methacrylic acid (MAA) along with acrylamide (AM). To explain the adsorption behavior, adsorption kinetics and isotherms were studied. Magnetic halloysite nanotubes molecularly imprinted polymers prepared from MAA (MHNTs-MIP1) displayed a high adsorption capacity (349 µg mg-1) toward NOR. A magnetic imprinting  solid phase extraction method  coupled  with  high  performance  liquid  chromatography  (MHNTs-MISPE-HPLC-UV) was  developed  for  the  determination of NOR  in  serum  and  water samples, by applying MHNTs-MIP as a sorbent. The recoveries from 83.76% to 103.30% in water and from 90.46% to 99.78% in serum were obtained. Besides remarquable mechanical properties and specific recognition of MHNTs-MIP toward template molecule. It could be also collected and separated fastly by external magnetic field. Moreover, MHNTs-MIPs could be reused for several cycles with the recovery range from 83.25% to 100.96% for  water sample and from 85.65% to 100.33% for serum sample. These analytical results of serum and  water samples showed that the proposed method based on MHNTs-MIPs is applicable for fast and selective extraction of therapeutic agents from biological fluids and environmental water.

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QbD Approach by Computer Aided Design and Response Surface Methodology for Molecularly Imprinted Polymer Based on Magnetic Halloysite Nanotubes for Extraction of Norfloxacin from Real Samples

Molecular mechanisms of environmental exposures and human disease

Thiourea derivatives acting as functional monomers of As(Ш) molecular imprinted polymers: A theoretical and experimental study on binding mechanisms.

Lipidomics and transcriptomics insight into impacts of microplastics exposure on hepatic lipid metabolism in mice

Lipidomics and transcriptomics insight into impacts of microplastics exposure on hepatic lipid metabolism in mice.

Whole transcriptome sequencing analysis revealed key RNA profiles and toxicity in mice after chronic exposure to microplastics.

Computer simulation assisted preparation and application of myclobutanil imprinted nanoparticles

Transcriptome-wide m6A modification mediates cardiotoxicity in mice after chronic exposure to microplastics.

Size controlled synthesis and fluorescence quenching behavior of N-CQDs based on molecular sieves

Bismuth-based materials have been widely studied and applied in the environmental and energy fields owing to their suitable energy band gap and unique layer structure, among which BiOX in bismuth-based materials has recently become a popular research topic. To improve the performance of BiOX materials, the design of heterojunctions is an effective way. In this paper, we summarize some synthetic methods of BiOX-based heterojunctions in recent years, focusing on the charge transfer pathways and photocatalytic mechanisms of conventional type II heterojunctions, Z-scheme heterojunctions, p-n heterojunctions and S-scheme heterojunctions. The paper also reviews an overview of BiOX-based heterojunction materials for specific applications in the energy and environmental fields. Finally, the possible factors affecting the photocatalytic performance of BiOX-based heterojunctions are presented and the prospects and challenges for their development are discussed. 

Jun Li Shi

Papers

Whole transcriptome sequencing analysis revealed key RNA profiles and toxicity in mice after chronic exposure to microplastics.

Computer simulation assisted preparation and application of myclobutanil imprinted nanoparticles

Transcriptome-wide m6A modification mediates cardiotoxicity in mice after chronic exposure to microplastics.

Size controlled synthesis and fluorescence quenching behavior of N-CQDs based on molecular sieves

Current status of research on BiOX-based heterojunction photocatalytic systems: Synthesis methods, photocatalytic applications and prospects