J
Jun Nosuke Hayashida
Researcher at Kyushu University
Publications - 34
Citations - 1397
Jun Nosuke Hayashida is an academic researcher from Kyushu University. The author has contributed to research in topics: Dacryoadenitis & Biopsy. The author has an hindex of 17, co-authored 32 publications receiving 1134 citations.
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Journal ArticleDOI
Th2 and regulatory immune reactions contribute to IgG4 production and the initiation of Mikulicz disease
Akihiko Tanaka,Masafumi Moriyama,Hitoshi Nakashima,Katsuhisa Miyake,Jun Nosuke Hayashida,Takashi Maehara,Shouichi Shinozaki,Yoshiaki Kubo,Seiji Nakamura +8 more
TL;DR: The results suggest that the pathogenesis of Mikulicz disease is different from that of SS, a unique inflammatory disorder characterized by Th2 and regulatory immune reactions that might play key roles in IgG4 production.
Journal ArticleDOI
Interleukin-21 contributes to germinal centre formation and immunoglobulin G4 production in IgG4-related dacryoadenitis and sialoadenitis, so-called Mikulicz's disease
Takashi Maehara,Masafumi Moriyama,Hitoshi Nakashima,Katsuhisa Miyake,Jun Nosuke Hayashida,Akihiko Tanaka,Shouichi Shinozaki,Yoshiaki Kubo,Seiji Nakamura +8 more
TL;DR: Results suggest that overexpression of IL-21 by Th2 cells might play a key role in GC formation and IgG4 production in IgG 4-DS.
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Preferential M2 macrophages contribute to fibrosis in IgG4-related dacryoadenitis and sialoadenitis, so-called Mikulicz's disease.
Sachiko Furukawa,Masafumi Moriyama,Akihiko Tanaka,Takashi Maehara,Hiroto Tsuboi,Mana Iizuka,Jun Nosuke Hayashida,Miho Ohta,Takako Saeki,Kenji Notohara,Takayuki Sumida,Seiji Nakamura +11 more
TL;DR: Results indicate that IL-10 and CCL18 secreted by preferential M2 macrophages possibly play a key role in the development of severe fibrosis in IgG4-DS.
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CD163+CD204+ tumor-associated macrophages contribute to T cell regulation via interleukin-10 and PD-L1 production in oral squamous cell carcinoma
Keigo Kubota,Masafumi Moriyama,Sachiko Furukawa,Haque A.S.M. Rafiul,Yasuyuki Maruse,Teppei Jinno,Akihiko Tanaka,Miho Ohta,Noriko Ishiguro,Masaaki Yamauchi,Mizuki Sakamoto,Takashi Maehara,Jun Nosuke Hayashida,Shintaro Kawano,Tamotsu Kiyoshima,Seiji Nakamura +15 more
TL;DR: The results suggest that CD163+CD204+ TAMs possibly play a key role in the invasion and metastasis of OSCC by T-cell regulation via IL-10 and PD-L1 production.
Journal ArticleDOI
Interleukin-33 produced by M2 macrophages and other immune cells contributes to Th2 immune reaction of IgG4-related disease.
Sachiko Furukawa,Masafumi Moriyama,Kensuke Miyake,Hitoshi Nakashima,Akihiko Tanaka,Takashi Maehara,Mana Iizuka-Koga,Mana Iizuka-Koga,Hiroto Tsuboi,Jun Nosuke Hayashida,Noriko Ishiguro,Masaki Yamauchi,Takayuki Sumida,Seiji Nakamura +13 more
TL;DR: The data suggest that IL-33 produced by M2 macrophages might contribute to the pathogenesis of IgG4-RD via aberrant activation of Th2 immune responses.