J
Jun Zhang
Researcher at Center for Drug Evaluation and Research
Publications - 83
Citations - 3369
Jun Zhang is an academic researcher from Center for Drug Evaluation and Research. The author has contributed to research in topics: Nephrotoxicity & Cardiotoxicity. The author has an hindex of 32, co-authored 74 publications receiving 3191 citations. Previous affiliations of Jun Zhang include National Institutes of Health & Food and Drug Administration.
Papers
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Journal ArticleDOI
Pulmonary Langerhans cell granulomatosis (histiocytosis X). A clinicopathologic study of 48 cases.
William D. Travis,Zea Borok,James H. Roum,Jun Zhang,Irwin M. Feuerstein,Victor J. Ferrans,Ronald G. Crystal +6 more
TL;DR: The frequent finding of intraluminal fibrosis and the frequent peribronchiolar location of PLCG lesions are consistent with the concept that in adults this disorder is associated with an abnormal response to cigarette smoke.
Journal ArticleDOI
Comparison of Kidney Injury Molecule-1 and Other Nephrotoxicity Biomarkers in Urine and Kidney Following Acute Exposure to Gentamicin, Mercury, and Chromium
Yuzhao Zhou,Vishal S. Vaidya,Ronald P. Brown,Jun Zhang,Barry A. Rosenzweig,Karol L. Thompson,Terry J. Miller,Joseph V. Bonventre,Peter L. Goering +8 more
TL;DR: Urinary Kim- 1 and kidney Kim-1/Havcr1 expression appear to be sensitive and tissue-specific biomarkers that will improve detection of early acute kidney injury following exposure to nephrotoxic chemicals and drugs.
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Correlation Between Serum Levels of Cardiac Troponin-T and the Severity of the Chronic Cardiomyopathy Induced by Doxorubicin
Eugene H. Herman,Jun Zhang,Steven E. Lipshultz,Nader Rifai,Douglas P. Chadwick,Kazuyo Takeda,Zu Xi Yu,Victor J. Ferrans +7 more
TL;DR: Measurements of serum levels of cardiac troponin-T (cTnT) seem to provide a sensitive means for assessing the early cardiotoxicity of doxorubicin.
Journal Article
Use of Cardiac Troponin T Levels as an Indicator of Doxorubicin-induced Cardiotoxicity
Eugene H. Herman,Steven E. Lipshultz,Nader Rifai,Jun Zhang,Thomas Papoian,Zu Xi Yu,Kazuyo Takeda,Victor J. Ferrans +7 more
TL;DR: Monitoring serum levels of cardiac troponin T can detect doxorubicin-induced myocyte damage in SHR and may prove useful for the noninvasive evaluation of this toxicity in humans.
Journal ArticleDOI
Doxorubicin-induced Apoptosis in Spontaneously Hypertensive Rats: Differential Effects in Heart, Kidney and Intestine, and Inhibition by ICRF-187☆
TL;DR: The data support the concept that the chronic cardiomyopathy induced by doxorubicin is not mediated by apoptosis of the cardiac myocytes, as well as showing that significant toxicity in the heart, kidneys and intestine in association with apoptosis in epithelial cells of the intestinal mucosa and renal tubules is induced.