J
Junchao Xu
Researcher at Chinese Academy of Sciences
Publications - 13
Citations - 987
Junchao Xu is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Metastasis & Immune system. The author has an hindex of 9, co-authored 13 publications receiving 473 citations. Previous affiliations of Junchao Xu include Center for Excellence in Education.
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Journal ArticleDOI
Biomimetic Metal-Organic Framework Nanoparticles for Cooperative Combination of Antiangiogenesis and Photodynamic Therapy for Enhanced Efficacy.
Huan Min,Jing Wang,Jing Wang,Yingqiu Qi,Yingqiu Qi,Yinlong Zhang,Yinlong Zhang,Xuexiang Han,Xuexiang Han,Ying Xu,Ying Xu,Junchao Xu,Junchao Xu,Yao Li,Long Chen,Long Chen,Keman Cheng,Guangna Liu,Na Yang,Na Yang,Yiye Li,Yiye Li,Guangjun Nie,Guangjun Nie +23 more
TL;DR: A biomimic, multifunctional nanoparticle‐based PDT agent, combining a tumor‐targeted photosensitizer with GSH scavenging and antiangiogenesis therapy, is developed that significantly improves their tumor inhibition efficiency.
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Engineering Biomimetic Platesomes for pH-Responsive Drug Delivery and Enhanced Antitumor Activity.
Guangna Liu,Guangna Liu,Guangna Liu,Xiao Zhao,Yinlong Zhang,Yinlong Zhang,Junchao Xu,Junchao Xu,Jiaqi Xu,Jiaqi Xu,Yao Li,Huan Min,Jian Shi,Ying Zhao,Ying Zhao,Jingyan Wei,Jing Wang,Jing Wang,Guangjun Nie,Guangjun Nie +19 more
TL;DR: A convenient way to incorporate stimuli‐responsive features into biomimetically nanoparticles is described, demonstrating the potential of engineered cell membranes as biomimetic camouflages for a new generation of biocompatible and efficient nanocarriers.
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Targeted Brain Delivery of Rabies Virus Glycoprotein 29-Modified Deferoxamine-Loaded Nanoparticles Reverses Functional Deficits in Parkinsonian Mice
Linhao You,Linhao You,Jing Wang,Jing Wang,Tianqing Liu,Yinlong Zhang,Yinlong Zhang,Xuexiang Han,Xuexiang Han,Ting Wang,Shanshan Guo,Shanshan Guo,Tian-Yu Dong,Junchao Xu,Junchao Xu,Gregory J. Anderson,Qiang Liu,Yan Zhong Chang,Xin Lou,Guangjun Nie,Guangjun Nie +20 more
TL;DR: A DFO-based nanoformulation modified with brain-targeting peptide rabies virus glycoprotein (RVG) 29 that can intracerebrally deliver DFO and holds great promise for delivery of DFO into the brain and for realizing iron chelation therapy in PD treatment.
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Engineered Nanoplatelets for Targeted Delivery of Plasminogen Activators to Reverse Thrombus in Multiple Mouse Thrombosis Models
Junchao Xu,Junchao Xu,Yinlong Zhang,Yinlong Zhang,Jiaqi Xu,Jiaqi Xu,Guangna Liu,Guangna Liu,Chunzhi Di,Chunzhi Di,Xiao Zhao,Xiao Zhao,Xiang Li,Yao Li,Ningbo Pang,Chengzhi Yang,Yanyi Li,Bozhao Li,Bozhao Li,Zefang Lu,Zefang Lu,Meifang Wang,Meifang Wang,Kesheng Dai,Rong Yan,Suping Li,Suping Li,Guangjun Nie,Guangjun Nie +28 more
TL;DR: The tailor‐designed nanoplatelets efficiently accumulate at the thrombi in pulmonary embolism and mesenteric arterial thrombosis model mice, eliciting a significantly enhanced thrombolysis activity compared to free rt‐PA.
Journal ArticleDOI
Bacterial Outer Membrane Vesicles Presenting Programmed Death 1 for Improved Cancer Immunotherapy via Immune Activation and Checkpoint Inhibition.
Yao Li,Yao Li,Yao Li,Ruifang Zhao,Ruifang Zhao,Keman Cheng,Keman Cheng,Keman Cheng,Kaiyue Zhang,Kaiyue Zhang,Yazhou Wang,Yazhou Wang,Yinlong Zhang,Yinlong Zhang,Yujing Li,Yujing Li,Guangna Liu,Guangna Liu,Junchao Xu,Junchao Xu,Jiaqi Xu,Jiaqi Xu,Gregory J. Anderson,Jian Shi,Jian Shi,Lei Ren,Xiao Zhao,Xiao Zhao,Guangjun Nie,Guangjun Nie +29 more
TL;DR: The development of genetically engineered OMVs whose surface has been modified by insertion of the ectodomain of programmed death 1 (PD1) demonstrates the potential of bioengineered OMVs as effective immunotherapeutic agents that can comprehensively regulate the tumor immune microenvironment to effect markedly increased anti-tumor efficacy.