Junhua Pan

TL;DR: This work studies the amount and direction of motion of virus particles suspended in thin vitrified ice layers across holes in perforated carbon films using exposure series and shows how alignment and averaging of movie frames can be used to restore high-resolution detail in images affected by beam-induced motion.

TL;DR: This work shows that it can align frames of movies, recorded with a direct electron detector during beam exposure of rotavirus double-layered particles, thereby greatly reducing image blurring caused by beam-induced motion and sample stage instabilities and increases the efficiency of cryo-EM imaging.

TL;DR: The result shows that a combination of cryoEM and molecular modeling can yield details of the antigen-antibody interface, although small variation in the twist of the rod-likeHA trimer limited the overall resolution to about 4.5Å.

TL;DR: A stepwise algorithm outperforms IGRA assays to accurately identify MTB infections by the combination IFN-γ, IL-2, and IL-4, and the sensitivity for detecting Mycobacterium tuberculosis (MTB) infections was significantly increased.

TL;DR: The integration of transcriptomics and metabolomics provides an effective means to elucidate AGM’s therapeutic pathways and biomarkers and demonstrated that AGM improved septic liver injury by regulating lipid metabolism, and reduced the inflammatory reaction by affecting fatty acid metabolism, amino acid metabolism and the arachidonic acid metabolism pathway.