J
Junichi Hitomi
Researcher at Osaka University
Publications - 12
Citations - 2269
Junichi Hitomi is an academic researcher from Osaka University. The author has contributed to research in topics: Unfolded protein response & Endoplasmic reticulum. The author has an hindex of 11, co-authored 12 publications receiving 2177 citations. Previous affiliations of Junichi Hitomi include Japan Society for the Promotion of Science.
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Journal ArticleDOI
Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Aβ-induced cell death
Junichi Hitomi,Junichi Hitomi,Taiichi Katayama,Taiichi Katayama,Yutaka Eguchi,Yutaka Eguchi,Takashi Kudo,Manabu Taniguchi,Manabu Taniguchi,Yoshihisa Koyama,Yoshihisa Koyama,Takayuki Manabe,Takayuki Manabe,Satoru Yamagishi,Satoru Yamagishi,Yoshio Bando,Kazunori Imaizumi,Yoshihide Tsujimoto,Yoshihide Tsujimoto,Masaya Tohyama,Masaya Tohyama +20 more
TL;DR: Caspase-4 can function as an ER stress-specific caspase in humans, and may be involved in pathogenesis of Alzheimer's disease.
Journal ArticleDOI
Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response
Taiichi Katayama,Kazunori Imaizumi,Naoya Sato,Ko Miyoshi,Takashi Kudo,Junichi Hitomi,Takashi Morihara,Takunari Yoneda,Fumi Gomi,Yasutake Mori,Yuka Nakano,Junji Takeda,T. Tsuda,Yasuto Itoyama,Ohoshi Murayama,Akihiko Takashima,Peter St George-Hyslop,Masatoshi Takeda,Masaya Tohyama +18 more
TL;DR: It is reported that mutations in PS1 affect the unfolded-protein response (UPR), which responds to the increased amount of unfolded proteins that accumulate in the endoplasmic reticulum (ER) under conditions that cause ER stress.
Journal ArticleDOI
Induction of neuronal death by ER stress in Alzheimer's disease.
Taiichi Katayama,Kazunori Imaizumi,Takayuki Manabe,Junichi Hitomi,Takashi Kudo,Masaya Tohyama +5 more
TL;DR: It was clarified what molecules related to cell death are activated in the case of AD and it was discovered that caspase-4 plays a key role in ER stress-induced apoptosis.
Journal ArticleDOI
Apoptosis induced by endoplasmic reticulum stress depends on activation of caspase-3 via caspase-12.
Junichi Hitomi,Taiichi Katayama,Manabu Taniguchi,Akiko Honda,Kazunori Imaizumi,Masaya Tohyama,Masaya Tohyama +6 more
TL;DR: It is suggested that activation of ER-resident caspase-12 indirectly activates cytoplasmic caspases-3 and might be important in ER stress-induced neuronal apoptosis.
Journal ArticleDOI
Increased Production of β-Amyloid and Vulnerability to Endoplasmic Reticulum Stress by an Aberrant Spliced Form of Presenilin 2
Naoya Sato,Kazunori Imaizumi,Takayuki Manabe,Manabu Taniguchi,Junichi Hitomi,Taiichi Katayama,Takunari Yoneda,Takashi Morihara,Yuichi Yasuda,Tsutomu Takagi,Takashi Kudo,T. Tsuda,Yasuto Itoyama,Takao Makifuchi,Paul E. Fraser,Peter St George-Hyslop,Masaya Tohyama +16 more
TL;DR: It is reported that PS2V protein impaired the signaling pathway of the unfolded protein response, similarly to familial AD-linked PS1 mutants and caused significant increases in the production of both amyloid β40 and β42.