Junko Ueda

TL;DR: High L1 copy number in schizophrenia was demonstrated in neurons from prefrontal cortex of patients and in induced pluripotent stem (iPS) cell-derived neurons containing 22q11 deletions, suggesting hyperactive retrotransposition of L1 in neurons triggered by environmental and/or genetic risk factors may contribute to the susceptibility and pathophysiology of schizophrenia.

TL;DR: High variation in DNA methylation in neuronal nuclei is found, suggesting that neuronal cells have more potential ability to change their epigenetic status in response to developmental and environmental conditions compared with non-neuronal cells in the central nervous system.

TL;DR: This is the first study to report the role of epigenetic modification of SLC6A4 in BD using an unbiased approach, which provides an insight for its pathophysiology.

TL;DR: DNA methylation sites of SLC6A4, which were hypermethylated in patients with bipolar disorder, were hypomethylated in the neuroblastoma cells treated with mood stabilizers, and this finding will contribute to a better understanding of the epigenetic changes associated with mood disorders.

TL;DR: LCLs should be used for DNA methylation studies with caution as the methylation patterns of promoter regions in LCLs are not always the same as those in PBLs, and hypermethylation was more predominant than hypomethylation in L CLs compared with PBLS.