J
Jürg Utzinger
Researcher at Office of Population Research
Publications - 8
Citations - 953
Jürg Utzinger is an academic researcher from Office of Population Research. The author has contributed to research in topics: Biomarker discovery & Metabolome. The author has an hindex of 7, co-authored 8 publications receiving 918 citations. Previous affiliations of Jürg Utzinger include University of Basel & Imperial College London.
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Efficacy and cost-effectiveness of environmental management for malaria control.
TL;DR: In view of fewer adverse ecological effects, increased sustainability and better uses of local resources and knowledge, environmental management – integrated with pharmacological, insecticidal and bednet interventions – could substantially increase the chances of rolling back malaria.
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Metabonomic and microbiological analysis of the dynamic effect of vancomycin-induced gut microbiota modification in the mouse
Ivan K. S. Yap,Jia V. Li,Jasmina Saric,François-Pierre Martin,Huw M. L. Davies,Yulan Wang,Ian D. Wilson,Jeremy K. Nicholson,Jürg Utzinger,Julian R. Marchesi,Elaine Holmes +10 more
TL;DR: Metabolic profiling, coupled with the metagenomic study of this antibiotic model, illustrates the close inter-relationship between the host and microbial "metabotypes", and will provide a basis for further experiments probing the understanding of the microbial-mammalian metabolic axis.
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Species Variation in the Fecal Metabolome Gives Insight into Differential Gastrointestinal Function
Jasmina Saric,Yulan Wang,Jia V. Li,Muireann Coen,Jürg Utzinger,Julian R. Marchesi,Jennifer Keiser,Kirill Veselkov,John C. Lindon,Jeremy K. Nicholson,Elaine Holmes +10 more
TL;DR: The systematic characterization of fecal composition across humans, mice, and rats, together with the evaluation of inherent variation, provides a benchmark for future studies seeking to determine fecal biomarkers of disease and/or response to dietary or therapeutic interventions.
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Global metabolic responses of mice to Trypanosoma brucei brucei infection.
Yulan Wang,Jürg Utzinger,Jasmina Saric,Jia V. Li,Jean Burckhardt,Stephan Dirnhofer,Jeremy K. Nicholson,Burton H. Singer,Reto Brun,Elaine Holmes +9 more
TL;DR: Concluding, parasite infection results in multiple systemic biochemical effects in the host and disturbance of the symbiotic gut microbial metabolic interactions, which may underpin the development of new diagnostic criteria and metrics of therapeutic efficacy.
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Global Metabolic Responses of NMRI Mice to an Experimental Plasmodium berghei Infection
Jia V. Li,Yulan Wang,Jasmina Saric,Jeremy Nicholson,Stephan Dirnhofer,Burton H. Singer,Marcel Tanner,Sergio Wittlin,Elaine Holmes,Jürg Utzinger +9 more
TL;DR: In this article, a top-down system biology approach was used to characterize metabolic changes in the mouse resulting from infection with Plasmodium berghei, using high-resolution (1)H NMR spectroscopy and multivariate data analysis techniques.