Y
Yulan Wang
Researcher at Nanyang Technological University
Publications - 189
Citations - 12270
Yulan Wang is an academic researcher from Nanyang Technological University. The author has contributed to research in topics: Gut flora & Virtual screening. The author has an hindex of 58, co-authored 186 publications receiving 10765 citations. Previous affiliations of Yulan Wang include Office of Population Research & Chinese Academy of Sciences.
Papers
More filters
Journal ArticleDOI
Rapid and Noninvasive Metabonomic Characterization of Inflammatory Bowel Disease
Julian R. Marchesi,Elaine Holmes,Fatima Khan,Sunil Kochhar,Pauline D. Scanlan,Fergus Shanahan,Ian D. Wilson,Yulan Wang +7 more
TL;DR: The first characterization of fecal extracts obtained from patients with CD and UC is presented by employing a noninvasive metabonomics approach, which combines high resolution 1H NMR spectroscopy and multivariate pattern recognition techniques, suggesting changes in the gut microbial community.
Journal ArticleDOI
A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model
François-Pierre Martin,François-Pierre Martin,Marc-Emmanuel Dumas,Yulan Wang,Cristina Legido-Quigley,Ivan K. S. Yap,Huiru Tang,Severine Zirah,Gerard M. Murphy,Olivier Cloarec,John C. Lindon,Norbert Sprenger,Laurent B. Fay,Sunil Kochhar,Peter J. van Bladeren,Elaine Holmes,Jeremy K. Nicholson +16 more
TL;DR: Data indicate that the microbiome modulates absorption, storage and the energy harvest from the diet at the systems level, impacting directly on the host's ability to metabolize lipids.
Journal ArticleDOI
Probiotic modulation of symbiotic gut microbial–host metabolic interactions in a humanized microbiome mouse model
François-Pierre Martin,François-Pierre Martin,Yulan Wang,Norbert Sprenger,Ivan K. S. Yap,Torbjörn Lundstedt,Per Lek,Serge Rezzi,Ziad Ramadan,Peter J. van Bladeren,Laurent B. Fay,Sunil Kochhar,John C. Lindon,Elaine Holmes,Jeremy K. Nicholson +14 more
TL;DR: The integrated system investigations demonstrate the potential of metabolic profiling as a top‐down systems biology driver for investigating the mechanistic basis of probiotic action and the therapeutic surveillance of the gut microbial activity related to dietary supplementation of probiotics.
Journal ArticleDOI
Colonization-Induced Host-Gut Microbial Metabolic Interaction
Sandrine P. Claus,Sandrine L. Ellero,Bernard Berger,Lutz Krause,Anne Bruttin,Jérôme Molina,Alain Paris,Elizabeth J. Want,Isabelle de Waziers,Olivier Cloarec,Selena E. Richards,Yulan Wang,Marc-Emmanuel Dumas,Alastair B. Ross,Serge Rezzi,Sunil Kochhar,Peter J. van Bladeren,John C. Lindon,Elaine Holmes,Jeremy K. Nicholson +19 more
TL;DR: Strong associations of the Coriobacteriaceae family are revealed with both the hepatic triglyceride, glucose, and glycogen levels and the metabolism of xenobiotics, the first evidence of an in vivo association between a family of bacteria and hepatic lipid metabolism.
Journal ArticleDOI
High-resolution magic-angle-spinning NMR spectroscopy for metabolic profiling of intact tissues
Olaf Beckonert,Muireann Coen,Hector C. Keun,Yulan Wang,Timothy M. D. Ebbels,Elaine Holmes,John C. Lindon,Jeremy K. Nicholson +7 more
TL;DR: This protocol details the analysis of intact tissue samples by means of high-resolution magic-angle-spinning (HR-MAS) NMR spectroscopy and provides a detailed description of sample collection, preparation and analysis.