R
Roger L. Nation
Researcher at Monash University
Publications - 399
Citations - 23404
Roger L. Nation is an academic researcher from Monash University. The author has contributed to research in topics: Colistin & Polymyxin B. The author has an hindex of 75, co-authored 384 publications receiving 20335 citations. Previous affiliations of Roger L. Nation include Repatriation General Hospital & Monash University, Clayton campus.
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Journal ArticleDOI
Colistin: the re-emerging antibiotic for multidrug-resistant Gram-negative bacterial infections
Jian Li,Roger L. Nation,John D. Turnidge,Robert W. Milne,Kingsley Coulthard,Kingsley Coulthard,Craig R Rayner,David L. Paterson +7 more
TL;DR: Recent progress in understanding the complex chemistry, pharmacokinetics, and pharmacodynamics of colistin, the interplay between these three aspects, and their effect on the clinical use of this important antibiotic are summarized.
Journal ArticleDOI
Polymyxin B for the treatment of multidrug-resistant pathogens: a critical review
TL;DR: Since polymyxins will be increasingly used for the treatment of infections caused by MDR bacteria, clinical pharmacokinetic, pharmacodynamic and toxicodynamic studies underpinning the optimal use of these drugs are urgently required.
Journal ArticleDOI
Colistin Resistance in Acinetobacter baumannii Is Mediated by Complete Loss of Lipopolysaccharide Production
Jennifer H. Moffatt,Marina Harper,Marina Harper,Paul Harrison,John Df Hale,Evgeny Vinogradov,Torsten Seemann,Rebekah Henry,Bethany Crane,Frank St. Michael,Andrew D. Cox,Ben Adler,Ben Adler,Roger L. Nation,Jian Li,John D. Boyce,John D. Boyce +16 more
TL;DR: It is shown that A. baumannii can rapidly develop resistance to polymyxin antibiotics by complete loss of the initial binding target, the lipid A component of lipopolysaccharide (LPS), which has long been considered to be essential for the viability of Gram-negative bacteria.
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Population Pharmacokinetics of Colistin Methanesulfonate and Formed Colistin in Critically Ill Patients from a Multicenter Study Provide Dosing Suggestions for Various Categories of Patients
Samira M. Garonzik,Jian Li,Jian Li,Visanu Thamlikitkul,David L. Paterson,Shmuel Shoham,Jovan Jacob,Fernanda P. Silveira,Alan Forrest,Roger L. Nation +9 more
TL;DR: Model-fitted parameter estimates were used to derive suggested loading and maintenance dosing regimens for various categories of patients, including those on hemodialysis and continuous renal replacement, and colistin may best be used as part of a highly active combination.
Journal ArticleDOI
Structure—Activity Relationships of Polymyxin Antibiotics
TL;DR: This research presents a novel and scalable approaches that allow for real-time decision-making in the design and implementation of drug 505(b) agonist regimens for the treatment of central nervous system disorders.