J
Justin R. Bailey
Researcher at Johns Hopkins University School of Medicine
Publications - 76
Citations - 4170
Justin R. Bailey is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Virus & Viral replication. The author has an hindex of 29, co-authored 61 publications receiving 3419 citations. Previous affiliations of Justin R. Bailey include Johns Hopkins University.
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Journal ArticleDOI
Residual Human Immunodeficiency Virus Type 1 Viremia in Some Patients on Antiretroviral Therapy Is Dominated by a Small Number of Invariant Clones Rarely Found in Circulating CD4+ T Cells
Justin R. Bailey,Ahmad R. Sedaghat,Tara L. Kieffer,Timothy P. Brennan,Patricia K. Lee,Megan Wind-Rotolo,Christine M. Haggerty,Ashrit R. Kamireddi,Yi Liu,Jessica Lee,Deborah Persaud,Joel E. Gallant,Joseph Cofrancesco,Thomas C. Quinn,Thomas C. Quinn,Claus O. Wilke,Stuart C. Ray,Janet D. Siliciano,Richard E. Nettles,Robert F. Siliciano,Robert F. Siliciano +20 more
TL;DR: In some patients on antiretroviral therapy, the major mechanism for residual viremia involves prolonged production of a small number of viral clones without evident evolution, possibly by cells other than circulating CD4+ T cells.
Journal ArticleDOI
Isolation and Characterization of Replication-Competent Human Immunodeficiency Virus Type 1 from a Subset of Elite Suppressors
Joel N. Blankson,Justin R. Bailey,Seema M. Thayil,Hung-Chih Yang,Kara G. Lassen,Jun Lai,Jun Lai,Shiv Gandhi,Janet D. Siliciano,Thomas M. Williams,Robert F. Siliciano,Robert F. Siliciano +11 more
TL;DR: The results suggest that some ES are infected with HIV-1 isolates that are fully replication competent and that long-term immunologic control of replication-competent HIV- 1 is possible.
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Maintenance of viral suppression in HIV-1-infected HLA-B*57+elite suppressors despite CTL escape mutations
TL;DR: Analysis of low level viremia reveals an unexpectedly high level of CTL escape mutations reflecting selective pressure acting at HLA-B*57–restricted epitopes in ES, providing the first direct evidence that most ES experience chronic low levelviremia.
Journal ArticleDOI
Clearance of hepatitis C infection is associated with the early appearance of broad neutralizing antibody responses.
William O. Osburn,Anna E. Snider,Brittany L. Wells,Rachel Latanich,Justin R. Bailey,David L. Thomas,Andrea L. Cox,Stuart C. Ray +7 more
TL;DR: Control ofHCV infection is associated with more rapid development of a broad nAb response, independent of the infection viral genotype, providing further evidence for the role of nAb in controlling HCV infection and the potential benefit of generating broad anti‐HCV nAb responses by vaccination.
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Nuclear retention of multiply spliced HIV-1 RNA in resting CD4+ T cells.
Kara G. Lassen,Kasra X. Ramyar,Justin R. Bailey,Yan Zhou,Robert F. Siliciano,Robert F. Siliciano +5 more
TL;DR: The ability of PTB to reverse latency without inducing cellular activation is a result with therapeutic implications, as the nuclear retention of MS HIV-1 RNA interrupts a positive feedback loop and contributes to the non-productive nature of infection of resting CD4+ T cells.