J
Justine N. deGruyter
Researcher at Scripps Research Institute
Publications - 14
Citations - 961
Justine N. deGruyter is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Carboxylation & Diastereomer. The author has an hindex of 8, co-authored 13 publications receiving 636 citations. Previous affiliations of Justine N. deGruyter include New Mexico State University & Torrey Pines Institute for Molecular Studies.
Papers
More filters
Journal ArticleDOI
Residue-Specific Peptide Modification: A Chemist’s Guide
TL;DR: This guide will help triage candidate methods for peptide alteration and will serve as a starting point for those seeking to solve long-standing challenges.
Journal ArticleDOI
Electrochemically Driven, Ni-Catalyzed Aryl Amination: Scope, Mechanism, and Applications
Yu Kawamata,Julien C. Vantourout,David P. Hickey,Peng Bai,Longrui Chen,Qinglong Hou,Wenhua Qiao,Koushik Barman,Martin A. Edwards,Alberto F. Garrido-Castro,Justine N. deGruyter,Hugh Nakamura,Kyle W. Knouse,Chuanguang Qin,Khalyd J. Clay,Denghui Bao,Chao Li,Jeremy T. Starr,Carmen N. Garcia-Irizarry,Neal W. Sach,Henry S. White,Matthew Neurock,Shelley D. Minteer,Phil S. Baran +23 more
TL;DR: Through a series of electrochemical, computational, kinetic, and empirical experiments, the key mechanistic features of this reaction have been unraveled, leading to a second generation set of conditions that is applicable to a broad range of aryl halides and amine nucleophiles.
Journal ArticleDOI
Unlocking P(V): Reagents for chiral phosphorothioate synthesis
Kyle W. Knouse,Justine N. deGruyter,Michael A. Schmidt,Bin Zheng,Julien C. Vantourout,Cian Kingston,Stephen E. Mercer,Ivar M. McDonald,Richard E. Olson,Ye Zhu,Chao Hang,Jason Zhu,Changxia Yuan,Qinggang Wang,Peter K. Park,Martin D. Eastgate,Phil S. Baran +16 more
TL;DR: The invention of a P(V)-based reagent platform for programmable, traceless, diastereoselective phosphorus-sulfur incorporation and the power of this reagent system is demonstrated through the robust and stereocontrolled synthesis of various nucleotidic architectures, including ASOs and CDNs, via an efficient, inexpensive, and operationally simple protocol.
Journal ArticleDOI
Alkyl Sulfinates: Radical Precursors Enabling Drug Discovery
TL;DR: This review seeks to highlight those particularly compelling cases published in the past 5 years of sulfinates, with an eye toward the identification of robust and predictable trends in reactivity.
Journal ArticleDOI
Peptide Macrocyclization Inspired by Non-Ribosomal Imine Natural Products.
Lara R. Malins,Justine N. deGruyter,Kevin J. Robbins,Paul Michael Scola,Martin D. Eastgate,M. Reza Ghadiri,Phil S. Baran +6 more
TL;DR: Structural interrogation of the linear and macrocyclic peptides using variable-temperature NMR and circular dichroism suggests that preorganization of linear substrates is not a prerequisite for macrocyclization.