C
Chao Li
Researcher at Tsinghua University
Publications - 50
Citations - 1948
Chao Li is an academic researcher from Tsinghua University. The author has contributed to research in topics: Aryl & Alkyl. The author has an hindex of 17, co-authored 46 publications receiving 1418 citations. Previous affiliations of Chao Li include Tianjin University & Scripps Research Institute.
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Journal ArticleDOI
A general alkyl-alkyl cross-coupling enabled by redox-active esters and alkylzinc reagents.
Tian Qin,Josep Cornella,Chao Li,Lara R. Malins,Jacob T. Edwards,Shuhei Kawamura,Brad D. Maxwell,Martin D. Eastgate,Phil S. Baran +8 more
TL;DR: This study demonstrates how the same activating principles used for decades to make simple C–N (amide) bonds from carboxylic acids with loss of water can be used to make C–C bonds through coupling with dialkylzinc reagents and loss of carbon dioxide.
Journal ArticleDOI
Electrochemically Enabled, Nickel-Catalyzed Amination.
Chao Li,Yu Kawamata,Hugh Nakamura,Julien C. Vantourout,Zhiqing Liu,Qinglong Hou,Denghui Bao,Jeremy T. Starr,Jinshan Chen,Ming Yan,Phil S. Baran +10 more
TL;DR: The work herein demonstrates the potential of utilizing electrochemistry to provide a complementary avenue to access such critical bonds using an inexpensive nickel catalyst under mild reaction conditions.
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Electrochemically Driven, Ni-Catalyzed Aryl Amination: Scope, Mechanism, and Applications
Yu Kawamata,Julien C. Vantourout,David P. Hickey,Peng Bai,Longrui Chen,Qinglong Hou,Wenhua Qiao,Koushik Barman,Martin A. Edwards,Alberto F. Garrido-Castro,Justine N. deGruyter,Hugh Nakamura,Kyle W. Knouse,Chuanguang Qin,Khalyd J. Clay,Denghui Bao,Chao Li,Jeremy T. Starr,Carmen N. Garcia-Irizarry,Neal W. Sach,Henry S. White,Matthew Neurock,Shelley D. Minteer,Phil S. Baran +23 more
TL;DR: Through a series of electrochemical, computational, kinetic, and empirical experiments, the key mechanistic features of this reaction have been unraveled, leading to a second generation set of conditions that is applicable to a broad range of aryl halides and amine nucleophiles.
Journal ArticleDOI
Hydromethylation of Unactivated Olefins
TL;DR: A solution to the classic unsolved problem of olefin hydromethylation is presented and this highly chemoselective method can tolerate labile and reactive chemical functionalities and uses a simple set of reagents.
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Electrochemically Enabled, Nickel-Catalyzed Dehydroxylative Cross-Coupling of Alcohols with Aryl Halides.
TL;DR: In this article, the combination of anodic preparation of the alkoxy triphenylphosphonium ion and nickel-catalyzed cathodic reductive cross-coupling provides an efficient method to construct C(sp2)-C(sp3) bonds, in which free alcohols and bromides can be directly used as coupling partners.