J
Jutta Heinrich
Researcher at University of Ulm
Publications - 3
Citations - 442
Jutta Heinrich is an academic researcher from University of Ulm. The author has contributed to research in topics: Protein subunit & Gene. The author has an hindex of 3, co-authored 3 publications receiving 409 citations.
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Journal ArticleDOI
Genetic and Functional Analyses of SHANK2 Mutations Suggest a Multiple Hit Model of Autism Spectrum Disorders
Claire S. Leblond,Jutta Heinrich,Richard Delorme,Christian Proepper,Catalina Betancur,Guillaume Huguet,Marina Konyukh,Pauline Chaste,Elodie Ey,Maria Råstam,Henrik Anckarsäter,Gudrun Nygren,I. Carina Gillberg,Jonas Melke,Roberto Toro,Béatrice Regnault,Fabien Fauchereau,Oriane Mercati,Nathalie Lemière,David Skuse,Martin Poot,Richard Holt,Anthony P. Monaco,Irma Järvelä,Katri Kantojärvi,Raija Vanhala,Sarah Curran,David A. Collier,Patrick Bolton,Andreas G. Chiocchetti,Sabine M. Klauck,Fritz Poustka,Christine M. Freitag,Regina Waltes,Marnie Kopp,Eftichia Duketis,Elena Bacchelli,Fiorella Minopoli,Liliana Ruta,Agatino Battaglia,Luigi Mazzone,Elena Maestrini,Ana Filipa Sequeira,Bárbara Oliveira,Astrid M. Vicente,Guiomar Oliveira,Dalila Pinto,Stephen W. Scherer,Diana Zelenika,Marc Delepine,Mark Lathrop,Dominique Bonneau,Vincent Guinchat,Françoise Devillard,Brigitte Assouline,Marie-Christine Mouren,Marion Leboyer,Christopher Gillberg,Tobias M. Boeckers,Thomas Bourgeron +59 more
TL;DR: The identification of a novel 421 kb de novo SHANK2 deletion in a patient with autism strengthens the role of synaptic gene dysfunction in ASD but also highlights the presence of putative modifier genes, in keeping with the “multiple hit model” for ASD.
Journal ArticleDOI
Heterogeneous nuclear ribonucleoprotein k interacts with Abi-1 at postsynaptic sites and modulates dendritic spine morphology.
Christian Proepper,Konrad Steinestel,Michael J. Schmeisser,Jutta Heinrich,Julie Steinestel,Juergen Bockmann,Stefan Liebau,Tobias M. Boeckers +7 more
TL;DR: Heterogeneous nuclear ribonucleoprotein K (hnRNPK), a 65 kDa ssDNA/RNA-binding-protein that is involved in multiple intracellular signaling cascades, is identified as a binding partner of Abi-1 at postsynaptic sites and shows obvious similarities regarding both protein knockdown phenotypes.
Journal ArticleDOI
The dynactin p150 subunit: cell biology studies of sequence changes found in ALS/MND and Parkinsonian Syndromes
Marianne Stockmann,Marie Meyer-Ohlendorf,Kevin Achberger,Stefan Putz,Maria Demestre,Haishan Yin,Corinna Hendrich,Leonhard Linta,Jutta Heinrich,Cornelia Brunner,Christian Proepper,Georges F. Kuh,Bernd Baumann,Torben Langer,Birgit Schwalenstöcker,Kerstin E. Braunstein,Christine A. F. von Arnim,Stephan Schneuwly,Thomas Meyer,Philip C. Wong,Tobias M. Boeckers,Albert C. Ludolph,Stefan Liebau +22 more
TL;DR: The results suggest the presence of biological changes caused by some p150 mutants pointing to a potential pathogenetic significance as modifier of the phenotype of the human disease.