C
Christian Proepper
Researcher at University of Ulm
Publications - 25
Citations - 1639
Christian Proepper is an academic researcher from University of Ulm. The author has contributed to research in topics: Postsynaptic density & Postsynaptic potential. The author has an hindex of 18, co-authored 24 publications receiving 1502 citations.
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Journal ArticleDOI
Genetic and Functional Analyses of SHANK2 Mutations Suggest a Multiple Hit Model of Autism Spectrum Disorders
Claire S. Leblond,Jutta Heinrich,Richard Delorme,Christian Proepper,Catalina Betancur,Guillaume Huguet,Marina Konyukh,Pauline Chaste,Elodie Ey,Maria Råstam,Henrik Anckarsäter,Gudrun Nygren,I. Carina Gillberg,Jonas Melke,Roberto Toro,Béatrice Regnault,Fabien Fauchereau,Oriane Mercati,Nathalie Lemière,David Skuse,Martin Poot,Richard Holt,Anthony P. Monaco,Irma Järvelä,Katri Kantojärvi,Raija Vanhala,Sarah Curran,David A. Collier,Patrick Bolton,Andreas G. Chiocchetti,Sabine M. Klauck,Fritz Poustka,Christine M. Freitag,Regina Waltes,Marnie Kopp,Eftichia Duketis,Elena Bacchelli,Fiorella Minopoli,Liliana Ruta,Agatino Battaglia,Luigi Mazzone,Elena Maestrini,Ana Filipa Sequeira,Bárbara Oliveira,Astrid M. Vicente,Guiomar Oliveira,Dalila Pinto,Stephen W. Scherer,Diana Zelenika,Marc Delepine,Mark Lathrop,Dominique Bonneau,Vincent Guinchat,Françoise Devillard,Brigitte Assouline,Marie-Christine Mouren,Marion Leboyer,Christopher Gillberg,Tobias M. Boeckers,Thomas Bourgeron +59 more
TL;DR: The identification of a novel 421 kb de novo SHANK2 deletion in a patient with autism strengthens the role of synaptic gene dysfunction in ASD but also highlights the presence of putative modifier genes, in keeping with the “multiple hit model” for ASD.
Journal ArticleDOI
Concerted action of zinc and ProSAP/Shank in synaptogenesis and synapse maturation
Andreas M. Grabrucker,Andreas M. Grabrucker,Mary Jane Knight,Christian Proepper,Juergen Bockmann,Marisa K. Joubert,Magali Rowan,G UIrich Nienhaus,Craig C. Garner,James U. Bowie,Michael R. Kreutz,Eckart D. Gundelfinger,Tobias M. Boeckers +12 more
TL;DR: It is reported that Zn2+ ions, which are highly enriched within the postsynaptic density (PSD), are able to influence the recruitment of ProSAP/Shank proteins to PSDs in a family member‐specific manner during the course of synaptogenesis and synapse maturation.
Concerted action of zinc and ProSAP/Shank in synaptogenesis and synapse maturation This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial Share Alike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resultingworkunderthesameorsimilarlicensetothisone.Theworkmustbeattributedbacktotheoriginalauthorand commercial use is not permitted without specific permission.
Andreas M. Grabrucker,Mary Jane Knight,Christian Proepper,Juergen Bockmann,Marisa K. Joubert,Magali Rowan,G UIrich Nienhaus,Craig C. Garner,James U. Bowie,Michael R. Kreutz,Tobias M. Boeckers +10 more
TL;DR: In this article, it was shown that Zn2+ ions, which are highly enriched within the postsynaptic density (PSD), are able to influence the recruitment of ProSAP/Shank proteins to PSDs in a family member-specific manner during the course of synaptogenesis and synapse maturation.
Journal ArticleDOI
Abelson interacting protein 1 (Abi-1) is essential for dendrite morphogenesis and synapse formation
Christian Proepper,Svenja Johannsen,Stefan Liebau,Janine Dahl,Bianca Vaida,Juergen Bockmann,Michael R. Kreutz,Eckart D. Gundelfinger,Tobias M. Boeckers +8 more
TL;DR: Data show that Abi‐1 can act as a specific synapto‐nuclear messenger and is essentially involved in dendrite and synapse formation, and co‐immunoprecipitates with the transcription factor complex of Myc/Max proteins and enhances E‐box‐regulated gene transcription.
Journal ArticleDOI
Modulation of Calcium-Activated Potassium Channels Induces Cardiogenesis of Pluripotent Stem Cells and Enrichment of Pacemaker-Like Cells
Alexander Kleger,Thomas Seufferlein,Daniela Malan,Michael Tischendorf,Alexander Storch,Anne Wolheim,Stephan Latz,Stephanie Protze,Marc Porzner,Christian Proepper,Cornelia Brunner,Sarah-Fee Katz,Ganesh V. Pusapati,Lars Bullinger,Wolfgang-Michael Franz,Ralf Koehntop,Klaudia Giehl,Andreas Spyrantis,Oliver H. Wittekindt,Quiong Lin,Martin Zenke,Bernd K. Fleischmann,Maria Wartenberg,Anna M. Wobus,Tobias M. Boeckers,Stefan Liebau +25 more
TL;DR: This work has applied the SKCa activator 1-ethyl-2-benzimidazolinone on embryonic stem cells and identified this particular ion channel family as a new critical target involved in the generation of cardiac pacemaker-like cells.