K.F. Chung

TL;DR: Bronchial biopsies in smokers with normal lung function and chronic obstructive pulmonary disease patients show increased expression of p65 protein, predominantly in the bronchial epithelium, indicating disease severity is associated with an increased epithelial expression of nuclear factor-κB.

TL;DR: A Task Force supported by the European Respiratory Society was set up in 1997 in order to address the major issues relevant to difficult/therapy-resistant asthma as mentioned in this paper, and the Task Force also concerned itself with defining the areas of research necessary to bring about a greater understanding of the causes of difficult asthma and novel treatments.

TL;DR: It is suggested that stable mild/moderate chronic obstructive pulmonary disease is associated with an active T‐helper 1 cell/type‐1 cytotoxic T‐cell inflammatory process involving activation of signal transducer and activator of transcription 4 and interferon-gamma production.

TL;DR: The data suggest that nitrosative stress, mainly mediated by MPO and neutrophilic inflammation, may contribute to the pathogenesis of severe COPD.

TL;DR: MIP-2 may be one chemokine that could contribute to IL-1 beta induced neutrophil influx and is suggested to be a viable candidate for local protein biosynthesis.