K Herzer

TL;DR: Concern is raised about the widespread combined use of GCs with antineoplastic drugs or agents in the clinical management of cancer patients because resistance toward cancer therapy-mediated apoptosis was induced in solid tumors of human cervix and lung carcinomas.

TL;DR: Results show that otherwise chemotherapy‐resistant tumor cells can be sensitized for TRAIL‐induced apoptosis at the DISC level in the presence of high levels of cFLIP, which suggests the existence of an additional factor that modulates the interaction of FADD and the TRAIL death receptors.

TL;DR: Evidence is presented for a cascade of molecular events that the virus initiates to subvert the innate immune attack and demonstrate a way in which HCV avoids recognition by NK cells that may contribute to the establishment of a chronic infection.

TL;DR: Data show that emetine is a strong inducer of apoptosis in leukemia cells and could be a suitable cytotoxic drug alone or in combination with other chemotherapeutics to sensitise leukemia cells to apoptosis.

TL;DR: In vitro and in vivo models for sensitive and resistant human NSCLC indicate that re‐expression of caspases might be an effective strategy to restore sensitivity for chemotherapy inNSCLC in vivo.