T
Tobias L. Haas
Researcher at Catholic University of the Sacred Heart
Publications - 36
Citations - 3875
Tobias L. Haas is an academic researcher from Catholic University of the Sacred Heart. The author has contributed to research in topics: Apoptosis & Programmed cell death. The author has an hindex of 24, co-authored 35 publications receiving 3494 citations. Previous affiliations of Tobias L. Haas include Istituto Superiore di Sanità & The Catholic University of America.
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Journal ArticleDOI
Linear ubiquitination prevents inflammation and regulates immune signalling
Björn Gerlach,Stefanie M. Cordier,Anna C. Schmukle,Christoph H. Emmerich,Christoph H. Emmerich,Eva Rieser,Tobias L. Haas,Andrew I. Webb,James A Rickard,Holly Anderton,W. Wei-Lynn Wong,Ueli Nachbur,Lahiru Gangoda,Uwe Warnken,Anthony W. Purcell,John Silke,Henning Walczak,Henning Walczak +17 more
TL;DR: It is concluded that by enabling linear ubiquitination in the TNF receptor signalling complex, SHARPIN interferes with TNF-induced cell death and, thereby, prevents inflammation.
Journal ArticleDOI
Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction
Tobias L. Haas,Christoph H. Emmerich,Christoph H. Emmerich,Bjã¶rn Gerlach,Bjã¶rn Gerlach,Anna C. Schmukle,Stefanie M. Cordier,Eva Rieser,Rebecca Feltham,James E Vince,Uwe Warnken,Till Wenger,Ronald Koschny,David Komander,John Silke,Henning Walczak,Henning Walczak +16 more
TL;DR: It is demonstrated that sustained stability of the T NF-RSC requires LUBAC's enzymatic activity, thereby adding a third form of ubiquitin linkage to the triggering of TNF signaling by the TNF-R SC.
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Preclinical differentiation between apparently safe and potentially hepatotoxic applications of TRAIL either alone or in combination with chemotherapeutic drugs.
Tom M. Ganten,Ronald Koschny,Jaromir Sykora,Henning Schulze-Bergkamen,Peter Büchler,Tobias L. Haas,Manuela B. Schader,Andreas Untergasser,Wolfgang Stremmel,Henning Walczak +9 more
TL;DR: The data show that whereas TRAIL alone or together with selected chemotherapeutic drugs seems to be safe, the combination of TRAIL with cisplatin is toxic to PHH.
Journal ArticleDOI
Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs
Tom M. Ganten,Tobias L. Haas,Jaromir Sykora,Jaromir Sykora,Heiko Stahl,Martin R. Sprick,Stefanie C. Fas,Andreas Krueger,M. A. Weigand,Anne Grosse-Wilde,Wolfgang Stremmel,Peter H. Krammer,Henning Walczak +12 more
TL;DR: A potential mechanism for TRAIL sensitisation by 5-FU is the increased effectiveness of caspase-8 recruitment to and activation at the DISC facilitated by the downregulation of cFLIP and the consequent shift in the ratio of casing-8 to c FLIP at theDISC.
Journal ArticleDOI
Proteasome inhibition sensitizes hepatocellular carcinoma cells, but not human hepatocytes, to TRAIL
Tom M. Ganten,Tom M. Ganten,Ronald Koschny,Ronald Koschny,Tobias L. Haas,Jaromir Sykora,Jaromir Sykora,Min Li-Weber,K Herzer,Henning Walczak +9 more
TL;DR: Results show that otherwise chemotherapy‐resistant tumor cells can be sensitized for TRAIL‐induced apoptosis at the DISC level in the presence of high levels of cFLIP, which suggests the existence of an additional factor that modulates the interaction of FADD and the TRAIL death receptors.