Medicinal attributes of 1,2,3-triazoles: Current developments

Cu(I)-catalyzed azide–alkyne 1,3-dipolar cycloaddition (CuAAC), popularly known as the “click reaction”, serves as the most potent and highly dependable tool for facile construction of simple to complex architectures at the molecular level. Click-knitted threads of two exclusively different molecular entities have created some really interesting structures for more than 15 years with a broad spectrum of applicability, including in the fascinating fields of synthetic chemistry, medicinal science, biochemistry, pharmacology, material science, and catalysis. The unique properties of the carbohydrate moiety and the advantages of highly chemo- and regioselective click chemistry, such as mild reaction conditions, efficient performance with a wide range of solvents, and compatibility with different functionalities, together produce miraculous neoglycoconjugates and neoglycopolymers with various synthetic, biological, and pharmaceutical applications. In this review we highlight the successful advancement of Cu(I)...

Cu-Catalyzed Click Reaction in Carbohydrate Chemistry

Triazole derivatives and their anti-tubercular activity

Hybrid molecules: The privileged scaffolds for various pharmaceuticals

Quinoline: a promising antitubercular target

Synthesis of quinoline coupled [1,2,3]-triazoles as a promising class of anti-tuberculosis agents

A series of N-glycosylamine based organogelators were synthesized from 4,6-O-protected saccharides introducing pyridylamines. The gelation properties of these compounds were studied in regard to their molecular structure by scanning electron microscopy, differential scanning calorimetry, FT-IR spectroscopy and quantum chemical calculations.

Novel saccharide–pyridine based gelators: selective gelation and diversity in superstructures

Expedient synthesis of coumarin-coupled triazoles via 'click chemistry' leading to the formation of coumarin-triazole-sugar hybrids.

Serratia marcescens isolated from decaying coconut pith exhibited high lignolytic activity. Growth on indicator medium, analysis of residual indulin, and infra-red spectroscopic analysis indicated the lignolytic potential of the isolate. Ortho-Coumaric acid, ferulic acid, 2,3-dihydroxy cinnamic acid and protocatechuic acid were identified as intermediates involved in indulin degradation by S. marcescens. Qualitative confirmation and quantitative estimation of the intermediates were carried out by high performance thin layer chromatography (HPTLC).

K. Karthik Kumar

Papers

Synthesis of quinoline coupled [1,2,3]-triazoles as a promising class of anti-tuberculosis agents

Novel saccharide–pyridine based gelators: selective gelation and diversity in superstructures

Expedient synthesis of coumarin-coupled triazoles via 'click chemistry' leading to the formation of coumarin-triazole-sugar hybrids.

Degradation of indulin, a kraft pine lignin, by Serratia marcescens.

Synthesis of quinoline-based glycoconjugates: a facile one-pot three-component reaction.