Journal ArticleDOI
Synthesis of quinoline coupled [1,2,3]-triazoles as a promising class of anti-tuberculosis agents
TLDR
The efficiency and fidelity of the Cu(I)-catalyzed azide-alkyne reaction are substantiated by good yields and exclusive formation of the expected 1,4-disubstituted triazole product.About:
This article is published in Carbohydrate Research.The article was published on 2011-10-18. It has received 80 citations till now. The article focuses on the topics: Quinoline & Triazole.read more
Citations
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Journal ArticleDOI
Medicinal attributes of 1,2,3-triazoles: Current developments
TL;DR: The present work aims to summarize the current approaches adopted for the synthesis of the 1,2,3-triazole and medicinal significance of these architectures as a lead structure for the discovery of drug molecules such as COX-1/COX-2 inhibitors, HIV protease inhibitors, CB1 cannabinoid receptor antagonist and much more which are in the pipeline of clinical trials.
Journal ArticleDOI
Triazole derivatives and their anti-tubercular activity
TL;DR: Molecules containing triazole moiety may show promising in vitro and in vivo anti-TB activities and might be able to prevent the drug resistant to certain extent.
Journal ArticleDOI
Hybrid molecules: The privileged scaffolds for various pharmaceuticals
TL;DR: A comparison of the drug potency of the hybrid molecules with their individual counterparts is discussed for quantifying the significance of the concept of molecular hybridisation.
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Quinoline: a promising antitubercular target
TL;DR: The present review has collated published reports on this versatile core of quinoline to provide an insight so that its full therapeutic potential can be utilized for the treatment of tuberculosis.
Journal ArticleDOI
Triazole: A Promising Antitubercular Agent.
TL;DR: Triazole core is considered as a privileged structure in medicinal chemistry and is widely used as ‘parental’ compounds to synthesize molecules with medical benefits, especially with infection‐related activities and triazole as a potential targeted core moiety against tuberculosis is explored.
References
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Journal ArticleDOI
Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides.
TL;DR: A novel regiospecific copper(I)-catalyzed 1,3-dipolar cycloaddition of terminal alkynes to azides on solid-phase is reported, and the X-ray structure of 2-azido-2-methylpropanoic acid has been solved, to yield structural information on the 1, 3-dipoles entering the reaction.
Journal ArticleDOI
The growing impact of click chemistry on drug discovery.
TL;DR: The copper-(I)-catalyzed 1,2,3-triazole formation from azides and terminal acetylenes is a particularly powerful linking reaction, due to its high degree of dependability, complete specificity, and the bio-compatibility of the reactants.
Journal ArticleDOI
1,2,3-Triazole-[2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D- ribofuranosyl]-3'-spiro-5"-(4"-amino-1",2"-oxathiole 2",2"-dioxide) (TSAO) analogues: synthesis and anti-HIV-1 activity.
Rosa Alvarez,Sonsoles Velázquez,Ana San-Félix,Stefano Aquaro,Erik De Clercq,Carlo Federico Perno,Anna Karlsson,Jan Balzarini,María-José Camarasa +8 more
TL;DR: Several 4- or 5-monosubsituted and 4,5-disubstituted 1,2,3-triazole analogues of the anti-HIV-1 lead compound TSAO have been prepared and evaluated as inhibitors of HIV-1-induced cytopathicity.
PatentDOI
Programmable one-pot oligosaccharide synthesis
TL;DR: In this article, the reactivity of a number of p-methylphenyl thioglycoside (STol) donors which are either fully protected or have one hydroxyl group exposed has been quantitatively determined by HPLC in conjunction with the development of a broadly applicable approach for a facile one-pot synthesis of oligosaccharides.
Journal ArticleDOI
Evolution of tuberculosis control and prospects for reducing tuberculosis incidence, prevalence, and deaths globally.
TL;DR: Reduction of TB incidence, prevalence, and deaths by 2015 could be achieved in most of the world, but the challenge will be greatest in Africa and Eastern Europe.