K
K. Shanti Raju
Researcher at St Thomas' Hospital
Publications - 7
Citations - 342
K. Shanti Raju is an academic researcher from St Thomas' Hospital. The author has contributed to research in topics: Papillomaviridae & Transmission (mechanics). The author has an hindex of 7, co-authored 7 publications receiving 332 citations. Previous affiliations of K. Shanti Raju include King's College London.
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Journal ArticleDOI
Perinatal infection and persistence of human papillomavirus types 16 and 18 in infants
John Cason,Jeremy N. Kaye,Richard J. Jewers,Parminder K. Kambo,Jon M. Bible,Barbara Kell,Bhavneet Shergill,Farzin Pakarian,K. Shanti Raju,Jennifer M. Best +9 more
TL;DR: Investigation of whether HPV‐16 and ‐18 DNA in infants contaminated at delivery persists until they are 6 months of age found bimodal distribution of IgM seropositivity peaked between 2 and 5 and 13 and 16 years of age, suggesting that two distinct modes of transmission may occur.
Journal ArticleDOI
High risk of human papillomavirus type 16 infections and of development of cervical squamous intraepithelial lesions in systemic lupus erythematosus patients
Rahul Nath,Christine Mant,Jennifer Luxton,Graham R. V. Hughes,K. Shanti Raju,Phillip Shepherd,John Cason,John Cason +7 more
TL;DR: UK women with a recent SLE diagnosis had disturbingly elevated levels of HPV infections (particularly with European HPV-16 variants at a high viral load), abnormal cervical cytology, and SIL.
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Cervical lesions are associated with human papillomavirus type 16 intratypic variants that have high transcriptional activity and increased usage of common mammalian codons.
Jon M. Bible,Christine Mant,Jennifer M. Best,Barbara Kell,William G. Starkey,K. Shanti Raju,Paul T. Seed,Chandrima Biswas,Peter Muir,Jangu E. Banatvala,John Cason +10 more
TL;DR: Investigation of whether cervical neoplasia is associated with infection with HPV-16 intratypic variants was undertaken by using RFLP analyses in a study of 100 HPV- 16 DNA-positive women with or without neopl Asia, and correlation was observed in codon usage.
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Relationship between human papillomavirus infection and overexpression of p53 protein in cervical carcinomas and lymph node metastases
Saban Cavuslu,John R. Goodlad,Carl Hobbs,Angela M. Connor,K. Shanti Raju,Jennifer M. Best,John Cason +6 more
TL;DR: Investigating archival biopsies from 26 cervical cancer patients concluded that, although detectable p53 protein is a common feature of cervical carcinomas, it is not predictive of metastases and is independent of HPV infection.
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IL-2 Enhances Standard IFNγ/LPS Activation of Macrophage Cytotoxicity to Human Ovarian Carcinoma in Vitro: A Potential for Adoptive Cellular Immunotherapy
TL;DR: IL-2 augmented the standard IFNgamma/LPS method of activating peritoneal macrophage cell killing of human ovarian cancer cells in this in vitro system, and enhanced activation may improve the disappointing results of previous adoptive cellular immunotherapy human trials.