Novel pyrrolidine monomers bearing various functional groups are used to prepare oligomeric structures. The pyrrolidine monomers can be joined via standard phosphate linkages including phosphodiester, phosphorothioate, and phosphoramidate linkages. Useful functional groups include nucleobases as well as polar groups, hydrophobic groups, ionic groups, aromatic groups and/or groups that participate in hydrogen-bonding,

Pyrrolidine-containing monomers and oligomers

Protection for the Amino Group

Trans-4-hydroxy-L-proline, a useful and versatile chiral starting block

Bicyclic Conformationally Restricted Diamines

Synthesis of pyrrolidine C-nucleosides via Heck reaction.

Derivatives of the title ring system are prepared in enantiomerically pure form from trans-4-hydroxy-L-proline . The target compounds are precursors of antibacterial quinolone carboxylic acids.

Synthesis of (1R,4R)- and (1S,4S)-2,5-diazabicyclo[2.2.1]heptanes and their N-substituted derivatives

Synthesis of (1R,4R)‐ and (1S,4S)‐2,5‐Diazabicyclo(2.2.1)heptanes and Their N‐Substituted Derivatives.

Thieno[2,3-d]-1,2,3-thiadiazoles (1) react with carbon disulfide in a "Matryoshkatype" double compartment autoclave [1] to yield thieno[2,3-d]-1,3-dithiol-2-thiones (2). With BH3/Me2S the cyclic trithiocarbonate (2d) is cleaved and the product characterized after methylation as 4b. Compounds 7a and 7b are prepared via the thieno[2,3-d]-1,3-dithiolium salts (6) followed by NaBH4-reduction.

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Synthesis of Thieno[2,3-d]-1,3-dithiol-2-thiones from Thieno[2,3-d]-1,2,3-thiadiazoles: Matryoshka-type autoclave for high-temperature, high-pressure thermolysis microscale reactions

Kaberi Bhattacharya

Papers

Synthesis of (1R,4R)- and (1S,4S)-2,5-diazabicyclo[2.2.1]heptanes and their N-substituted derivatives

Synthesis of (1R,4R)‐ and (1S,4S)‐2,5‐Diazabicyclo(2.2.1)heptanes and Their N‐Substituted Derivatives.

Synthesis of Thieno[2,3-d]-1,3-dithiol-2-thiones from Thieno[2,3-d]-1,2,3-thiadiazoles: Matryoshka-type autoclave for high-temperature, high-pressure thermolysis microscale reactions