Novel pyrrolidine monomers bearing various functional groups are used to prepare oligomeric structures. The pyrrolidine monomers can be joined via standard phosphate linkages including phosphodiester, phosphorothioate, and phosphoramidate linkages. Useful functional groups include nucleobases as well as polar groups, hydrophobic groups, ionic groups, aromatic groups and/or groups that participate in hydrogen-bonding,

Pyrrolidine-containing monomers and oligomers

Compounds of Formula (I) and/or pharmaceutically acceptable salts, solvates or prodrugs thereof, or pharmaceutical compositions containing such compounds exhibit anti-inflammatory and immunomodulatory activity, and can be effective asCB2 receptor ligands in treating cancer and inflammatory, immunomodulatory or respiratory diseases or conditions.

Cannabinoid receptor ligands

Protection for the Amino Group

Trans-4-hydroxy-L-proline, a useful and versatile chiral starting block

Bicyclic Conformationally Restricted Diamines

Derivatives of the title ring system are prepared in enantiomerically pure form from trans-4-hydroxy-L-proline . The target compounds are precursors of antibacterial quinolone carboxylic acids.

Synthesis of (1R,4R)- and (1S,4S)-2,5-diazabicyclo[2.2.1]heptanes and their N-substituted derivatives

Synthesis of (1R,4R)‐ and (1S,4S)‐2,5‐Diazabicyclo(2.2.1)heptanes and Their N‐Substituted Derivatives.

Synthesis of (1R,4S,5R)-endo-N,N-dimethyl-2-azabicyclo[2.2.1]methanamine

Synthesis of (1S,4S)-2-Thia-5-azabicyclo(2.2.1)heptane.

Starting from trans-4-hydroxy-L-proline, (1R,4S,5R)-endo-N,N-dimethyl-2-azabicyclo[2.2.1]methanamine 1 has been synthesized. The target compound is precursor of antibacterial quinolone carboxylic acids.

S. M. Siddiqi

Papers

Synthesis of (1R,4R)- and (1S,4S)-2,5-diazabicyclo[2.2.1]heptanes and their N-substituted derivatives

Synthesis of (1R,4R)‐ and (1S,4S)‐2,5‐Diazabicyclo(2.2.1)heptanes and Their N‐Substituted Derivatives.

Synthesis of (1R,4S,5R)-endo-N,N-dimethyl-2-azabicyclo[2.2.1]methanamine

Synthesis of (1S,4S)-2-Thia-5-azabicyclo(2.2.1)heptane.

Synthesis of (1R,4S,5R)‐endo‐N,N‐Dimethyl‐2‐azabicyclo(2.2.1) methanamine.