K
Kacper Skakuj
Researcher at Northwestern University
Publications - 10
Citations - 208
Kacper Skakuj is an academic researcher from Northwestern University. The author has contributed to research in topics: Antigen & Spherical nucleic acid. The author has an hindex of 5, co-authored 10 publications receiving 120 citations. Previous affiliations of Kacper Skakuj include International Institute of Minnesota.
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Journal ArticleDOI
Rational vaccinology with spherical nucleic acids.
Shuya Wang,Lei Qin,Gokay Yamankurt,Kacper Skakuj,Ziyin Huang,Peng-Cheng Chen,Donye Dominguez,Andrew Lee,Bin Zhang,Chad A. Mirkin +9 more
TL;DR: How spherical nucleic acids (SNAs), an emerging class of nanotherapeutic materials, can be used to deliver peptide antigens and nucleic acid adjuvants to raise immune responses that kill cancer cells, reduce (or eliminate) tumor growth, and extend life in three established mouse tumor models is explored.
Journal ArticleDOI
Conjugation Chemistry-Dependent T-Cell Activation with Spherical Nucleic Acids
TL;DR: The role of peptide chemical conjugation to the DNA, which is used to load SNAs with antigens via hybridization, is explored in the context of APC activation and significantly augments the downstream T-cell response in terms of both activation and proliferation.
Journal ArticleDOI
Light-Responsive Colloidal Crystals Engineered with DNA.
Jinghan Zhu,Jinghan Zhu,Haixin Lin,Haixin Lin,Youngeun Kim,Youngeun Kim,Muwen Yang,Muwen Yang,Kacper Skakuj,Kacper Skakuj,Jingshan S. Du,Jingshan S. Du,Byeongdu Lee,George C. Schatz,George C. Schatz,Richard P. Van Duyne,Richard P. Van Duyne,Chad A. Mirkin,Chad A. Mirkin +18 more
TL;DR: A novel method for synthesizing and photopatterning colloidal crystals via light-responsive DNA via azobenzene-modified DNA is developed, and the size of the particles can be used to modulate the Tm window over which these structures are light- responsive.
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Mercury-Free Automated Synthesis of Guanidinium Backbone Oligonucleotides.
TL;DR: A new method for synthesizing deoxynucleic guanidine (DNG) oligonucleotides that uses iodine as a mild and inexpensive coupling reagent is reported, which should greatly increase the accessibility of cationic backbone modifications and assist in the development of oligo-based drugs.
Journal ArticleDOI
Development of Spherical Nucleic Acids for Prostate Cancer Immunotherapy.
Lei Qin,Shuya Wang,Donye Dominguez,Alan Long,Siqi Chen,Jie Fan,Jihae Ahn,Kacper Skakuj,Ziyin Huang,Andrew Lee,Chad A. Mirkin,Bin Zhang +11 more
TL;DR: The importance of the structural positioning of peptide antigens together with adjuvants within IS-SNAs to the efficacy of IS-SNA-based cancer immunotherapy is demonstrated, demonstrating the importance of cross-priming of antitumor immune responses in two prostate cancer models.