Kai Rausalu

TL;DR: Silymarin exhibited significant antiviral activity against chikungunya virus, reducing both CHIKV replication efficiency and down-regulating production of viral proteins involved in replication.

TL;DR: Berberine is effective in multiple cell types against a variety of CHIKV strains, also at a high multiplicity of infection, consolidating the potential of berberine as an antiviral drug and highlighting the importance of the MAPK signaling pathways in the alphavirus infectious cycle.

TL;DR: Efficient reverse genetic systems, genetically stable marker viruses and packaged replicons offer significant improvements for biological studies of ZIKV infection and disease, as well as for the development of antiviral approaches.

TL;DR: An infectious plasmid of SFV, pCMV-SFV4, was constructed; its toxic effect was eliminated by intron insertion in the capsid protein encoding region and it produced virus with properties identical to those of wild-type SFV.

TL;DR: Obatoclax is a novel inhibitor of endosomal acidification that prevents viral fusion and that could be pursued as a potential broad-spectrum antiviral candidate.