Tuula A. Nyman

TL;DR: A comprehensive overview of the current understanding of the physiological roles of EVs is provided, drawing on the unique EV expertise of academia-based scientists, clinicians and industry based in 27 European countries, the United States and Australia.

TL;DR: An EV isolation protocol is optimized and the quantity and protein content of EVs induced by different agonists are compared and activation-dependent variations render the use of protein content in sample normalization invalid.

TL;DR: The reported severe impairment of dendritic structures in the cerebellum and motor cortex of c-Jun N-terminal kinase 1 (JNK1)-deficient mice is reported, and a novel antagonism between JNK and ERK is revealed, potentially providing a mechanism for fine-tuning thedendritic arbor.

TL;DR: Investigation of the cellular response of strain GG toward bile under defined bioreactor conditions revealed significant reduction in the abundance of a protein catalyzing the synthesis of exopolysaccharides, whereas a protein dedicated for active removal of bile compounds from the cells was up-regulated, suggesting a role for these proteins in facilitating the well founded interaction of strainGG with the host mucus in the presence of sublethal doses of biles.

TL;DR: It is shown that HSV‐1 inhibits expression of type I IFN in human macrophages through ICP27‐dependent targeting of the TBK1‐activated STING signalsome.