Kai Wang

TL;DR: Comparison of the human and mouse TCRAC/TCRDC region with the previously reported mouse DNA sequence reveals homologous counterparts for the variable and joining (J) gene segments and both constant genes.

TL;DR: These studies support the contention that large-scale DNA sequencing projects of homologous regions of mouse and human will provide powerful new tools for studying the biology and evolution of loci such as the T-cell receptor and for identifying and posing new questions about the functions of conserved sequences.

TL;DR: A frequent null allele of the human V beta 18 gene is described, resulting from a nucleotide substitution that creates a stop codon (CGA<-->TGA), indicating that this is a frequent "hole in the repertoire."

TL;DR: The mouse T-cell receptor (TCR) alpha/delta locus was mapped using 17 V alpha and 4 V beta subfamily-specific probes and organization features that might influence the expression of specific V gene segments in gamma delta cells are provided.

TL;DR: It is found that T cells from type II collagen-immunized DBA/1-lac could transfer auricular chondritis to naive mice and the results suggest that the lysine residues at positions 129, 141, and 147 in P1, the arginine residue at position 227, and glutamic acid at position 230 in P2 might play an important role in the trimolecular interaction.