M
Mitchell Kronenberg
Researcher at La Jolla Institute for Allergy and Immunology
Publications - 100
Citations - 20716
Mitchell Kronenberg is an academic researcher from La Jolla Institute for Allergy and Immunology. The author has contributed to research in topics: Antigen & Natural killer T cell. The author has an hindex of 49, co-authored 100 publications receiving 19812 citations. Previous affiliations of Mitchell Kronenberg include California Institute of Technology & University of California, San Diego.
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Journal ArticleDOI
Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid.
Daniel Mucida,Yunji Park,Gisen Kim,Olga Turovskaya,Iain Scott,Mitchell Kronenberg,Hilde Cheroutre +6 more
TL;DR: The vitamin A metabolite retinoic acid is identified as a key regulator of TGF-β–dependent immune responses, capable of inhibiting the IL-6–driven induction of proinflammatory TH17 cells and promoting anti-inflammatory Treg cell differentiation, indicating that a common metabolite can regulate the balance between pro- and anti- inflammatory immunity.
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NKT cells: what's in a name?
TL;DR: This perspective article seeks to clarify which cells fall under the NKT-cell umbrella, and which might be best considered as separate.
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Toward an understanding of NKT cell biology: progress and paradoxes.
TL;DR: The activation of NKT cells paradoxically can lead either to suppression or stimulation of immune responses, and one cannot predict which will occur, and many investigators are hopeful that immune therapies can be developed based on NKT cell stimulation.
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Recognition of bacterial glycosphingolipids by natural killer T cells
Yuki Kinjo,Douglass Wu,Gisen Kim,Guo-Wen Xing,Michael A. Poles,Michael A. Poles,David D. Ho,Moriya Tsuji,Moriya Tsuji,Kazuyoshi Kawahara,Chi-Huey Wong,Mitchell Kronenberg +11 more
TL;DR: It is shown that most mouse and human NKT cells recognize glycosphingolipids from Sphingomonas, Gram-negative bacteria that do not contain lipopolysaccharide, and that these cells might be useful in providing protection from bacteria that cannot be detected by pattern recognition receptors such as Toll-like receptor 4.
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Tracking the response of natural killer T cells to a glycolipid antigen using CD1d tetramers.
Jennifer L. Matsuda,Jennifer L. Matsuda,Olga V. Naidenko,Laurent Gapin,Toshinori Nakayama,Masaru Taniguchi,Chyung Ru Wang,Yasuhiko Koezuka,Mitchell Kronenberg,Mitchell Kronenberg +9 more
TL;DR: It is shown that tetramers of mouse CD1d loaded with α-GalCer are a sensitive and highly specific reagent for identifying Vα14+ NK T cells and that α- GalCer–specific T lymphocytes are more widely distributed than was previously appreciated.