K
Kai Zhang
Researcher at University of Pittsburgh
Publications - 3
Citations - 397
Kai Zhang is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Vascular endothelial growth factor A & Peroxisome proliferator-activated receptor. The author has an hindex of 3, co-authored 3 publications receiving 220 citations.
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Journal ArticleDOI
Dysfunction of the neurovascular unit in ischemic stroke and neurodegenerative diseases: An aging effect
Wei Cai,Kai Zhang,Peiying Li,Ling Zhu,Jing Xu,Boyu Yang,Xiaoming Hu,Zhengqi Lu,Jun Chen,Jun Chen +9 more
TL;DR: The impacts of aging on each NVU component are described and the mechanisms by which aging increases NVU sensitivity to stroke and neurodegenerative diseases are discussed.
Journal ArticleDOI
Peroxisome proliferator-activated receptor γ (PPARγ): A master gatekeeper in CNS injury and repair.
Wei Cai,Tuo Yang,Huan Liu,Lijuan Han,Kai Zhang,Xiaoming Hu,Xuejing Zhang,Ke-Jie Yin,Yanqin Gao,Michael V. L. Bennett,Rehana K. Leak,Jun Chen,Jun Chen,Jun Chen +13 more
TL;DR: The therapeutic potential of PPARγ in stroke and brain trauma is reviewed and the novel role of PParγ in long-term tissue repair is highlighted, which lies at the apex of cell fate decisions and exerts profound effects on the chronic progression of acute injury conditions.
Journal ArticleDOI
Endothelium-Targeted Deletion of microRNA-15a/16-1 Promotes Poststroke Angiogenesis and Improves Long-Term Neurological Recovery
Ping Sun,Kai Zhang,Sulaiman H Hassan,Xuejing Zhang,Xuelian Tang,Hongjian Pu,R. Anne Stetler,Jun Chen,Jun Chen,Ke-Jie Yin,Ke-Jie Yin +10 more
TL;DR: Inhibition of miR-15a/16-1 function in cerebrovascular endothelium may be a legitimate therapeutic approach for stroke recovery and is a negative regulator for postischemic cerebral angiogenesis and long-term neurological recovery.