K
Ke-Jie Yin
Researcher at University of Pittsburgh
Publications - 68
Citations - 4170
Ke-Jie Yin is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Stroke & Endothelial stem cell. The author has an hindex of 29, co-authored 61 publications receiving 3320 citations. Previous affiliations of Ke-Jie Yin include Fudan University Shanghai Medical College & Veterans Health Administration.
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Journal ArticleDOI
The long noncoding RNA Malat1: Its physiological and pathophysiological functions
TL;DR: This review will summarize latest findings related to the physiologic and pathophysiological processes of Malat1 and discuss its therapeutic potentials.
Journal ArticleDOI
Matrix metalloproteinase-9 degrades amyloid-β fibrils in vitro and compact plaques in situ
Ping Yan,Xiaoyan Hu,Haowei Song,Ke-Jie Yin,Randall J. Bateman,John R. Cirrito,Qingli Xiao,Fong F. Hsu,John Turk,Jan Xu,Chung Y. Hsu,David M. Holtzman,Jin-Moo Lee +12 more
TL;DR: It is demonstrated that matrix metalloproteinase-9 (MMP-9) can degrade fAβ and that this ability is not shared by other sAβ-degrading enzymes examined, including endothelin-converting enzyme, insulin-degRading enzyme, and neprilysin.
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Matrix Metalloproteinases Expressed by Astrocytes Mediate Extracellular Amyloid-β Peptide Catabolism
Ke-Jie Yin,John R. Cirrito,Ping Yan,Xiaoyan Hu,Qingli Xiao,Xiaoou Pan,Randall J. Bateman,Haowei Song,Fong-Fu Hsu,John Turk,Jan Xu,Chung Y. Hsu,Jason C. Mills,David M. Holtzman,Jin-Moo Lee +14 more
TL;DR: Results suggest that matrix metalloproteinases (MMPs) may contribute to extracellular brain Aβ clearance by promoting Aβ catabolism.
Journal ArticleDOI
miR-497 regulates neuronal death in mouse brain after transient focal cerebral ischemia
Ke-Jie Yin,Zhen Deng,Huarong Huang,Milton H. Hamblin,Changqing Xie,Jifeng Zhang,Y. Eugene Chen +6 more
TL;DR: It is found that miR-497 is induced in mouse brain after transient middle cerebral artery occlusion and mouse N2A neuroblastoma cells after oxygen-glucose deprivation, and the possibility that this pathway may contribute to the pathogenesis of the ischemic brain injury in stroke is raised.
Journal ArticleDOI
Long Noncoding RNA Malat1 Regulates Cerebrovascular Pathologies in Ischemic Stroke.
TL;DR: The experiments have provided the first evidence that Malat1 plays anti-apoptotic and anti-inflammatory roles in brain microvasculature to reduce ischemic cerebral vascular and parenchymal damages and suggest that lncRNAs can be therapeutically targeted to minimize poststroke brain damage.