K
Kalaiarasan Ponnusamy
Researcher at Jawaharlal Nehru University
Publications - 16
Citations - 217
Kalaiarasan Ponnusamy is an academic researcher from Jawaharlal Nehru University. The author has contributed to research in topics: Cancer & Docking (molecular). The author has an hindex of 6, co-authored 16 publications receiving 131 citations.
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Journal ArticleDOI
Comparative Genomic Analysis Reveals Habitat-Specific Genes and Regulatory Hubs within the Genus Novosphingobium
Roshan Kumar,Helianthous Verma,Shazia Haider,Abhay Bajaj,Utkarsh Sood,Kalaiarasan Ponnusamy,Shekhar Nagar,Mallikarjun Shakarad,Ram Krishan Negi,Yogendra Singh,Jitendra P. Khurana,Jack A. Gilbert,Jack A. Gilbert,Jack A. Gilbert,Rup Lal +14 more
TL;DR: The results suggest that the phylogenetic relationships were mostly influenced by metabolic trait enrichment, which is possibly governed by the microenvironment of each microbe’s respective niche.
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A geminivirus betasatellite encoded βC1 protein interacts with PsbP and subverts PsbP-mediated antiviral defence in plants.
TL;DR: It is suggested that betasatellite‐encoded βC1 protein accomplishes counter‐defence by physical interaction with PsbP reducing the ability of PsbB to bind geminivirus DNA to establish infection.
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ERK2-ZEB1-miR-101-1 axis contributes to epithelial-mesenchymal transition and cell migration in cancer.
Kailash Chandra Mangalhara,Siddharth Manvati,Sunil Kumar Saini,Kalaiarasan Ponnusamy,Gaurav Agarwal,Suresh K. Abraham,Rameshwar N. K. Bamezai +6 more
TL;DR: How microRNA-101 (miR-101) regulates two independent processes of cellular metastasis by targeting pro-metastatic upstream regulatory transcription factors, ZEB1 and ZEB2, and downstream effector-actin modulators, RHOA and RAC1 is shown, providing a single target for therapeutic intervention.
Posted ContentDOI
ACE2 Homo-dimerization, Human Genomic variants and Interaction of Host Proteins Explain High Population Specific Differences in Outcomes of COVID19
Swarkar Sharma,Inderpal Singh,Shazia Haider,Md. Zubbair Malik,Kalaiarasan Ponnusamy,Ekta Rai +5 more
TL;DR: It is concluded that a higher expression of ACE2 is facilitated by natural variations, acting as Expression quantitative trait loci (eQTLs), with different frequencies in different populations, and several key host genes, like SLC6A19, ADAM17, RPS6, HNRNPA1, SUMO1, NACA, BTF3 and some other proteases as Cathepsins might have a critical role.
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Nuclear localization signal region in nuclear receptor PXR governs the receptor association with mitotic chromatin.
TL;DR: It is shown, for the first time, that mitotic chromatin association of this factor is mediated by the combined action of two zinc fingers present in the DNA-binding domain of PXR, and the nuclear localization signal (NLS) region appears to play a major role in this interaction with mitotic Chromatin.