S
Siddharth Manvati
Researcher at Jawaharlal Nehru University
Publications - 21
Citations - 512
Siddharth Manvati is an academic researcher from Jawaharlal Nehru University. The author has contributed to research in topics: Gene & Cancer. The author has an hindex of 10, co-authored 17 publications receiving 381 citations. Previous affiliations of Siddharth Manvati include Shri Mata Vaishno Devi University.
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Journal ArticleDOI
Coumarin: An emerging antiviral agent
TL;DR: The present state of understanding with a focus on coumarin's antiviral effect and their possible molecular mechanisms against Influenza virus, HIV, Hepatitis virus, Dengue virus and Chikungunya virus are summarized.
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Insulin enhances metabolic capacities of cancer cells by dual regulation of glycolytic enzyme pyruvate kinase M2
Mohd Askandar Iqbal,Farid Ahmad Siddiqui,Vibhor Gupta,Shilpi Chattopadhyay,Prakasam Gopinath,Bhupender Kumar,Siddharth Manvati,Noor Chaman,Rameshwar N. K. Bamezai +8 more
TL;DR: The study identifies new PKM2-mediated effects of insulin on cancer metabolism, thus, advancing the understanding of insulin’s role in cancer.
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miR-24-2 controls H2AFX expression regardless of gene copy number alteration and induces apoptosis by targeting antiapoptotic gene BCL-2: a potential for therapeutic intervention.
Niloo Srivastava,Siddharth Manvati,Siddharth Manvati,Archita Srivastava,Ranjana Pal,Ponnusamy Kalaiarasan,Ponnusamy Kalaiarasan,Shilpi Chattopadhyay,Sailesh Gochhait,Raina Dua,Rameshwar N. K. Bamezai,Rameshwar N. K. Bamezai +11 more
TL;DR: It was observed that H2AX gene expression was negatively correlated with miR-24-2 expression and not in accordance with the gene copy number status, both in cell lines and in sporadic breast tumor tissues, suggesting the potentiating effect of mir- 24-2-mediated apoptotic induction in human cancer cell lines treated with anticancer drugs.
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Synergistic combination of gemcitabine and dietary molecule induces apoptosis in pancreatic cancer cells and down regulates PKM2 expression.
Archana Pandita,Bhupender Kumar,Siddharth Manvati,Samantha Vaishnavi,Shashank K. Singh,Rameshwar N. K. Bamezai +5 more
TL;DR: The effectiveness of BA or TQ in combination with GCB to inhibit cell proliferation, induce apoptosis and down-regulate the expression of PKM2, reflects promise in pancreatic cancer treatment.
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Replication of type 2 diabetes candidate genes variations in three geographically unrelated Indian population groups.
Shafat Ali,Rupali Chopra,Rupali Chopra,Siddharth Manvati,Siddharth Manvati,Yoginder Pal Singh,Yoginder Pal Singh,Nabodita Kaul,Nabodita Kaul,Anita Behura,Anita Behura,Ankit Mahajan,Ankit Mahajan,P. K. Sehajpal,Subash Gupta,Manoj K. Dhar,Gagan B.N. Chainy,A.J.S. Bhanwer,Swarkar Sharma,Swarkar Sharma,Rameshwar N. K. Bamezai,Rameshwar N. K. Bamezai +21 more
TL;DR: The genetic variants in five candidate genes: TCF7L2, HHEX, ENPP1, IDE and FTO, are significantly associated with T2D susceptibility in combined population and the association of rs7903146 with blood glucose levels is observed, supporting the role of TCF 7L2 gene in blood glucose homeostasis.