Rameshwar N. K. Bamezai

TL;DR: One candidate nonsynonymous variant in Toll-like receptor 5 (TLR5) is experimentally characterized and it is shown that it leads to altered NF-κB signaling in response to bacterial flagellin.

TL;DR: A review of the involvement of PKM2 in various physiological pathways with possible functional implications is provided in this article, where a variety of pathways, protein-protein interactions, and nuclear transport suggests its potential to perform multiple nonglycolytic functions with diverse implications.

TL;DR: Constant evidence suggests a critical role played by the low‐activity‐dimeric PKM2 in tumor progression, supported by the identification of mutations which result in the down‐regulation of its activity and tumorigenesis in a nude mouse model.

TL;DR: This study makes an attempt to validate the exclusive presence of mtG10398A (Ala-->Thr) polymorphism in a haplotype constituting mtDNA haplogroup N and its sublineages, imparting this group a higher risk for breast cancer, based on the re-analyses of approximately 1000 complete human mtDNA sequences worldwide and collated information on 2334 individuals belonging to 18 regions in India.

TL;DR: An association analysis of more than 1,500 individuals from different case-control and family studies observations provide insight into the long standing host-pathogen relationship between human and mycobacteria and highlight the key role of the TLR pathway in infectious diseases.