This progress report is concerned primarily with problems relating to the structure and reactions of hydroxamic acids and N-hydroxyimides, and also surveys some of the biological activities of these compounds. Particular significance attaches to the Lossen rearrangement of O-acylated hydroxamic acids, which leads to isocyanates or their reaction products.

The Chemistry of Hydroxamic Acids and N-Hydroxyimides

Compounds of formula (I) are useful as therapeutic agents, by virtue of having MMP and TNF inhibitory activity.

Hydroxamic and carboxylic acid derivatives having mmp and tnf inhibitory activity

Dieser Fortschrittsbericht behandelt in erster Linie Probleme der Struktur und der Reaktionen der Hydroxamsauren und N-Hydroxyimide und gibt auserdem einen kurzen Uberblick uber einige der biologischen Wirkungen dieser Verbindungen. Besondere Bedeutung unter den Reaktionen hat die Lossen-Umlagerung von O-acylierten Hydroxamsauren, die zu Isocyanaten oder deren Folgeprodukten fuhrt.

Die Chemie der Hydroxamsäuren undN-Hydroxyimide

The effects of elicitation, carbon, and nitrogen sources, and precursors on cell growth and tropane alkaloid production in Datura stramonium cell cultures were studied. D. Stramonium cell cultures responded very well to elicitors in the late exponential phase. Addition of cell wall fragments of Phytophotora megasperma (Pmg) enhanced the final tropane alkaloid yield by fivefold compared with control culture. Supply of carbon culture. Supply of carbon and nitrogen sources, at a ratio (C/N) of up to 70, to cell cultures in the early stationary phase, suppressed tropane alkaloid production; whereas C/N rations beyond about 100 increased the final product yield by more than 100% compared to that of the control experiment. Total alkaloid production in the cell culture supplemented with phenylalanine and ornithine was five times higher that that in the control culture. Higher rations of tropine to tropic acid also stimulated alkaloid production. At a ratio of 20, the productivity was seven times higher that that in the control culture. Adding precursors at high concentrations (e.g., 3 to 10 mM) to the cell culture reduced the final cell yield by less than 40%, while elicitation did not affect the cell yield. On the other hand, cell yield in the cultures supplemented with carbon and nitrogen sources was influenced by the C/N ratio. The highest cell yield was obtained at C/N = 70. © 1993 Wiley & Sons, Inc.

Kamal K. Midha

Papers

Synthesis and Properties of Some Hypotensive N-Alkylaminopropionic Esters and N,N-Dialkylaminopropionic Esters and Their Hydroxamic Acids

Beta-aminopropionohydroxamic acids and beta-aminopropionic esters with hypotensive properties.

2-Methyl-3-(4-phenylpiperidino) propionohydroxamic acid hydrochloride - a new hypotensive agent

Transesterification Using Hydrogen Bromide in Diethyl Ether–A Means of Identifying Components of Mixtures of Fatty Esters