Showing papers in "European Journal of Pharmacology in 1970"

TL;DR: The most potent and specific neuroleptics seemed to influence mainly the brain DA mechanisms, both functionally and chemically.

TL;DR: The data were consistent with the conclusion that caffeine and theophylline can release norepinephrine and suggest consideration of an adrenergic component in examining their effects.

TL;DR: The in vitro studies showed neither NA uptake blocking activity nor any inhibitory effects on monoamine oxidase activity by FLA63, and the results with dopa suggest that DA cannot accumulate in high amounts in the NA storage granules.

TL;DR: The results obtained support the view that a decrease of brain 5-HT concentration antagonizes morphine analgesia, and the possible role of the other brain monoamines in the analgesic activity of morphine is discussed.

TL;DR: The time-course of 6-hydroxydopamine induced disappearance of endogenous noradrenaline in mouse heart and iris, its reappearance and changes in uptake-storage properties of the adrenergic nerves for norad Renaline have been investigated using biochemical, isotope and histochemical techniques.

TL;DR: The authors' studies indicate that reduced sympathetic activity with decreased production of catecholamines is at least one mode of action of catapresan, and it seems possible that the reduced sympatheticactivity is of importance for the diminished production of renin and aldosterone which occurs following cataprean.

TL;DR: The 5-HTP reversal of p-CPA effects on “conflict” suggests the possible interpretation that the p- CPA effects are due to serotonin (5-HT) depletion.

TL;DR: Amantadine pretreatment increased both 3 H-DA synthesis and release and the drug effect on striatal dopamine terminals is discussed with respect to its utilization in human Parkinsonism.

TL;DR: Study of the cardiovascular actions of pancuronium in dogs indicated that the compound was well tolerated even in relatively high doses, and a lack of adverse cardiovascular effects has already been demonstrated in several clinical reports.

TL;DR: Intestinal sacs of rats are morphologically intact after eversion but progressively lose structural integrity, while Sacs of golden hamster maintain integrity longer than those of rat.

TL;DR: There may be a variable relationship between the tissue concentration and synthesis rates of the monoamines under both normal conditions and lithium treatment, and the observed differences in the action of lithium on monoamines in the regions studied may be related to the morphology of these discrete areas.

TL;DR: It is suggested that neuroleptic phenothiazine analogues accelerate turnover of both dopamine and noradrenaline, and Neuroleptic properties seemed to be best correlated to an increased synthesis and turnover of dopamine.

TL;DR: The increase in tyrosine hydroxylase activity in the rat superior cervical ganglion produced by reserpine is abolished by decentralization or administration of the nicotinic blockers chlorisondamine and pempidine, but in the adrenal medulla either another cholinergic receptor or another neurotransmitter is involved in mediating the trans-synaptic increase.

TL;DR: It can be concluded from the results that in the case of adenosine and inosine there is a specific uptake mechanism in the cell, which is inhibited by dipyridamole, and this mechanism does not apply to adenine and hypoxanthine.

TL;DR: It is shown that brain dopamine is of major importance for the central stimulant action of dexamphetamine in reserpinized mice, and in normal animals both noradrenaline and dopamine appear to be of importance for this effect.

TL;DR: The synthesis of noradrenaline in the mouse was inhibited either by blocking dopamine β-hydroxylase with FLA-63 or tyrosine hydroxylases with H 44/68, taking as evidence for an interaction between DA and NA containing neurons in the brain.

TL;DR: Possible activation of α-adrenergic receptors at the level of the sympathetic centres in the brain stem by 2-(2,6-dichlorophenylamino)-2-imidazoline (St 155, Catapresan) was studied using α- adrenergic blocking drugs.

TL;DR: Racemic- and dextro-propranolol, as well as chlorpromazine, at concentrations above 5 × 10 −6 M caused a dose dependent inhibition of hypotonic hemolysis and decreased cardiac excitability, contractility and potassium efflux.

TL;DR: Biosynthesis of 3H-CA in discrete areas of the rat brain was examined after stereotaxic microinjection of3H-tyrosine and the effects of amphetamine and thioproperazine (TZ) on the accumulation of newly synthesized 2H-DA and 3H -NA were studied.

TL;DR: Thioproperazine pretreatment potentiated amphetamine induced release of 3 H-DA but it blocked the other pharmacological effects of amphetamine occurring in animals.

TL;DR: It is suggested, that low antral pH inhibits the release of gastrin and that the elevated antRAL pH caused by vagotomy stimulates its release.

TL;DR: In this paper, Δ 9 -Tetrahydrocannabinol (Δ 9 -THC) was found to be a potent stimulator of ACTH secretion, as evidenced by depletion of adrena ascorbic acid in rats.

TL;DR: Aortic smooth muscle from the so-called spontaneously hypertensive rat (SHR) did not exhibit supersensitivity or hyperreactivity to norepinephrine compared with two strains of normotensive Wistar rats.

TL;DR: The results obtained using Th1165a support the idea that the optimum structural requirements in a sympathomimetic amine might be different for stimulation of β-adrenoreceptors initiating bronchodilatation and those initiating cardiac stimulation.

TL;DR: Isoproterenol, hydralazine and phentolamine produced a highly significant rise in plasma renin activity of rats and this increase is understood to be a compensation mechanism that antagonizes the hypotension induced by these compounds.

TL;DR: The results indicate that the female of each species has both a more functional 5-HT system and a higher rate of rearing.

TL;DR: R 16341 is a new member of the potent and long-acting series of diphenylbutyl piperidine neuroleptics of which pimozide is the prototype and the pharmacological profile of R 16341 resembles that of typical neuroleptic compounds.

TL;DR: The increase in extensor hindlimb reflex activity was correlated with decreased amine levels in 5- HT neurons and sometimes associated with the appearance of 5-HT in the extraneuronal space immediatlely surrounding5-HT cell bodies and terminals.

TL;DR: Calcium, acetylcholine and electrical stimulation of the nuclei posterior, ventromedialis and anterior medialis caused an enhanced release of noradrenaline and its metabolites from the hypothalamus and the releasing effect of acetyl choline was dependent on the presence of calcium ions.

TL;DR: A difference in sensitivity suggests that Clonidine may not influence the efferent sympathetic neurone but could act upon neurones which intervene in the modulating pathways of the sympathetic centre from the periphery and from higher centres.