BIOE 402. Medical Technology Assessment. 2 or 3 hours. Bioentrepreneur course. Assessment of medical technology in the context of commercialization. Objectives, competition, market share, funding, pricing, manufacturing, growth, and intellectual property; many issues unique to biomedical products. Course Information: 2 undergraduate hours. 3 graduate hours. Prerequisite(s): Junior standing or above and consent of the instructor.

“Bioinformatics” 특집을 내면서

Models for the processes by which ideas and influence propagate through a social network have been studied in a number of domains, including the diffusion of medical and technological innovations, the sudden and widespread adoption of various strategies in game-theoretic settings, and the effects of "word of mouth" in the promotion of new products. Recently, motivated by the design of viral marketing strategies, Domingos and Richardson posed a fundamental algorithmic problem for such social network processes: if we can try to convince a subset of individuals to adopt a new product or innovation, and the goal is to trigger a large cascade of further adoptions, which set of individuals should we target?We consider this problem in several of the most widely studied models in social network analysis. The optimization problem of selecting the most influential nodes is NP-hard here, and we provide the first provable approximation guarantees for efficient algorithms. Using an analysis framework based on submodular functions, we show that a natural greedy strategy obtains a solution that is provably within 63% of optimal for several classes of models; our framework suggests a general approach for reasoning about the performance guarantees of algorithms for these types of influence problems in social networks.We also provide computational experiments on large collaboration networks, showing that in addition to their provable guarantees, our approximation algorithms significantly out-perform node-selection heuristics based on the well-studied notions of degree centrality and distance centrality from the field of social networks.

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Maximizing the Spread of Influence through a Social Network

The rapid increase in the performance of graphics hardware, coupled with recent improvements in its programmability, have made graphics hardware a compelling platform for computationally demanding tasks in a wide variety of application domains. In this report, we describe, summarize, and analyze the latest research in mapping general-purpose computation to graphics hardware. We begin with the technical motivations that underlie general-purpose computation on graphics processors (GPGPU) and describe the hardware and software developments that have led to the recent interest in this field. We then aim the main body of this report at two separate audiences. First, we describe the techniques used in mapping general-purpose computation to graphics hardware. We believe these techniques will be generally useful for researchers who plan to develop the next generation of GPGPU algorithms and techniques. Second, we survey and categorize the latest developments in general-purpose application development on graphics hardware. This survey should be of particular interest to researchers who are interested in using the latest GPGPU applications in their systems of interest.

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A Survey of General-Purpose Computation on Graphics Hardware

Caching is a technique to reduce peak traffic rates by prefetching popular content into memories at the end users. Conventionally, these memories are used to deliver requested content in part from a locally cached copy rather than through the network. The gain offered by this approach, which we term local caching gain, depends on the local cache size (i.e., the memory available at each individual user). In this paper, we introduce and exploit a second, global, caching gain not utilized by conventional caching schemes. This gain depends on the aggregate global cache size (i.e., the cumulative memory available at all users), even though there is no cooperation among the users. To evaluate and isolate these two gains, we introduce an information-theoretic formulation of the caching problem focusing on its basic structure. For this setting, we propose a novel coded caching scheme that exploits both local and global caching gains, leading to a multiplicative improvement in the peak rate compared with previously known schemes. In particular, the improvement can be on the order of the number of users in the network. In addition, we argue that the performance of the proposed scheme is within a constant factor of the information-theoretic optimum for all values of the problem parameters.

Fundamental Limits of Caching

A Survey of General-Purpose Computation on Graphics Hardware.

We analyze local search heuristics for the metric k-median and facility location problems. We define the locality gap of a local search procedure for a minimization problem as the maximum ratio of a locally optimum solution (obtained using this procedure) to the global optimum. For k-median, we show that local search with swaps has a locality gap of 5. Furthermore, if we permit up to p facilities to be swapped simultaneously, then the locality gap is 3+2/p. This is the first analysis of a local search for k-median that provides a bounded performance guarantee with only k medians. This also improves the previous known 4 approximation for this problem. For uncapacitated facility location, we show that local search, which permits adding, dropping, and swapping a facility, has a locality gap of 3. This improves the bound of 5 given by M. Korupolu, C. Plaxton, and R. Rajaraman [Analysis of a Local Search Heuristic for Facility Location Problems, Technical Report 98-30, DIMACS, 1998]. We also consider a capacitated facility location problem where each facility has a capacity and we are allowed to open multiple copies of a facility. For this problem we introduce a new local search operation which opens one or more copies of a facility and drops zero or more facilities. We prove that this local search has a locality gap between 3 and 4.

/pdf/local-search-heuristics-for-k-median-and-facility-location-1ongqonk44.pdf

Local Search Heuristics for k -Median and Facility Location Problems

In this paper, we analyze local search heuristics for the k-median and facility location problems. We define the {\em locality gap\/} of a local search procedure as the maximum ratio of a locally optimum solution (obtained using this procedure) to the global optimum. For k-median, we show that local search with swaps has a locality gap of exactly 5. When we permit p facilities to be swapped simultaneously then the locality gap of the local search procedure is exactly 3+2/p. This is the first analysis of local search for k-median that provides a bounded performance guarantee with only k medians. This also improves the previous known 4 approximation for this problem. For Uncapacitated facility location, we show that local search, which permits adding, dropping and swapping a facility, has a locality gap of exactly 3. This improves the 5 bound of Korupolu et al. We also consider a capacitated facility location problem where each facilitym has a capacity and we are allowed to open multiple copies of a facility. For this problem we introduce a new operation which opens one or more copies of a facility and drops zero or more facilities. We prove that local search which permits this new operation has a locality gap between 3 and 4.

/pdf/local-search-heuristic-for-k-median-and-facility-location-2pv5q48pah.pdf

Local search heuristic for k-median and facility location problems

We consider the problem of pipelined filters, where a continuous stream of tuples is processed by a set of commutative filters. Pipelined filters are common in stream applications and capture a large class of multiway stream joins. We focus on the problem of ordering the filters adaptively to minimize processing cost in an environment where stream and filter characteristics vary unpredictably over time. Our core algorithm, A-Greedy (for Adaptive Greedy), has strong theoretical guarantees: If stream and filter characteristics were to stabilize, A-Greedy would converge to an ordering within a small constant factor of optimal. (In experiments A-Greedy usually converges to the optimal ordering.) One very important feature of A-Greedy is that it monitors and responds to selectivities that are correlated across filters (i.e., that are nonindependent), which provides the strong quality guarantee but incurs run-time overhead. We identify a three-way tradeoff among provable convergence to good orderings, run-time overhead, and speed of adaptivity. We develop a suite of variants of A-Greedy that lie at different points on this tradeoff spectrum. We have implemented all our algorithms in the STREAM prototype Data Stream Management System and a thorough performance evaluation is presented.

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Adaptive ordering of pipelined stream filters

In sensor networks, data acquisition frequently takes place at low-capability devices. The acquired data is then transmitted through a hierarchy of nodes having progressively increasing network band-width and computational power. We consider the problem of executing queries over these data streams, posed at the root of the hierarchy. To minimize data transmission, it is desirable to perform "in-network" query processing: do some part of the work at intermediate nodes as the data travels to the root. Most previous work on in-network query processing has focused on aggregation and inexpensive filters. In this paper, we address in-network processing for queries involving possibly expensive conjunctive filters, and joins. We consider the problem of placing operators along the nodes of the hierarchy so that the overall cost of computation and data transmission is minimized. We show that the problem is tractable, give an optimal algorithm, and demonstrate that a simpler greedy operator placement algorithm can fail to find the optimal solution. Finally we define a number of interesting variations of the basic operator placement problem and demonstrate their hardness.

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Operator placement for in-network stream query processing

Web services are becoming a standard method of sharing data and functionality among loosely-coupled systems. We propose a general-purpose Web Service Management System (WSMS) that enables querying multiple web services in a transparent and integrated fashion. This paper tackles a first basic WSMS problem: query optimization for Select-Project-Join queries spanning multiple web services. Our main result is an algorithm for arranging a query's web service calls into a pipelined execution plan that optimally exploits parallelism among web services to minimize the query's total running time. Surprisingly, the optimal plan can be found in polynomial time even in the presence of arbitrary precedence constraints among web services, in contrast to traditional query optimization where the analogous problem is NP-hard. We also give an algorithm for determining the optimal granularity of data "chunks" to be used for each web service call. Experiments with an initial prototype indicate that our algorithms can lead to significant performance improvement over more straightforward techniques.

/pdf/query-optimization-over-web-services-qtoqh4syq4.pdf

Kamesh Munagala

Papers

Local Search Heuristics for k -Median and Facility Location Problems

Local search heuristic for k-median and facility location problems

Adaptive ordering of pipelined stream filters

Operator placement for in-network stream query processing

Query optimization over web services