Kaname Miyamoto

TL;DR: In this article, the authors showed that injection of lipopolysaccharide and D-galactosamine, at doses of 0.2 μg/kg and 800 mg/kg, respectively, elicited massive hepatic necrosis within 24 hr in C3H/HeN mice.

TL;DR: Pretreatment with dexamethasone or 16,16-dimethyl-prostaglandin E2 attenuated not only the elevation of plasma tumor necrosis factor-alpha activity but also the increase in plasma aminotransferase activity and improved the survival rate.

TL;DR: It is argued that the novel synthetic lipid A analogue E5531 can antagonize the action of L PS in in vitro and suppress the pathological effects of LPS in vivo in mice.

TL;DR: A quinone derivative useful in the treatment of hepatic diseases defined by the general formula: "STR1##" where R1 is selected from the group consisting of alkyl, alkenly, alkynyl or heterocycle, R2 is a substituted nitrogen containing radical wherein the substituents on said nitrogen are selected from a group consisting either of hydrogen, substituted or unsubstituted lower alkyls, and where said nitrogen may be a ring heteroatom, and R3, R4 and R5, may be the same or different and each

TL;DR: Findings indicate that E3330 has a suppressive effect on TNF-α generation from monocytes/macrophages, regardless of origin or species, and this effect is based in part on the suppression of T NF-α mRNA expression.