K
Karen Bean
Researcher at University of North Carolina at Chapel Hill
Publications - 8
Citations - 470
Karen Bean is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Superoxide dismutase & Paraquat. The author has an hindex of 5, co-authored 6 publications receiving 445 citations.
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Response of Pseudomonas aeruginosa to pyocyanin: mechanisms of resistance, antioxidant defenses, and demonstration of a manganese-cofactored superoxide dismutase.
TL;DR: Results demonstrate that P. aeruginosa resists pycyanin because of limited redox cycling of this compound and that under conditions favoring pyocyanin production, catalase and superoxide dismutase activities increase.
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Preliminary observations on lactoferrin secretion in human vaginal mucus: variation during the menstrual cycle, evidence of hormonal regulation, and implications for infection with Neisseria gonorrhoeae
TL;DR: Variation in vaginal lactoferrin concentration may result in alterations in susceptibility to bacterial pathogens such as Neisseriae gonorrhoeae, and vaginal lact oferrin appears to be under hormonal control.
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Role of extracellular iron in the action of the quinone antibiotic streptonigrin: mechanisms of killing and resistance of Neisseria gonorrhoeae.
Myron S. Cohen,Y. Chai,Bradley E. Britigan,W. R. Mckenna,Jessica L. Adams,T. Svendsen,Karen Bean,Daniel J. Hassett,P. F. Sparling +8 more
TL;DR: The results suggest that a membrane component may be a target for the actions of streptonigrin, and this antibiotic has also been used to select resistant bacterial mutants, some of which vary in iron utilization.
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Regulation of catalase in Neisseria gonorrhoeae. Effects of oxidant stress and exposure to human neutrophils.
TL;DR: The results suggest that catalase is an important defense for N. gonorrhoeae during attack by human neutrophils, and the rapid response of this enzyme to hydrogen peroxide should be taken into consideration in studies designed to evaluate the interaction between neutrophil and gonococci.
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The role of hydroxyl radical in chromosomal and plasmid damage in Neisseria gonorrhoeae in vivo.
TL;DR: DNA and RNA damage in viable organisms exposed to intracellular redox stress is demonstrated and the critical role of hydroxyl radical in this process is confirmed.