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Karen Giddens

Researcher at Halifax

Publications -  6
Citations -  726

Karen Giddens is an academic researcher from Halifax. The author has contributed to research in topics: Endothelial dysfunction & Endothelium. The author has an hindex of 5, co-authored 6 publications receiving 690 citations. Previous affiliations of Karen Giddens include Queen Elizabeth II Health Sciences Centre.

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Oral glucose loading acutely attenuates endothelium-dependent vasodilation in healthy adults without diabetes: an effect prevented by vitamins C and E.

TL;DR: Oral glucose loading causes an acute, transient decrease of endothelium-dependent flow-mediated dilation of the brachial artery in healthy subjects without diabetes, which is prevented by vitamins C and E, indicating that vitamins prevented the glucose-induced attenuation of FMD.
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Effect of folic acid and antioxidant vitamins on endothelial dysfunction in patients with coronary artery disease

TL;DR: Folic acid supplementation significantly improved endothelial dysfunction in patients with coronary atherosclerosis, and further clinical trials are required to determine whether folic Acid supplementation may reduce cardiovascular events.
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Folic acid improves endothelial dysfunction in type 2 diabetes--an effect independent of homocysteine-lowering.

TL;DR: 2 weeks of folic acid supplementation can improve endothelial dysfunction in type 2 diabetics independent of homocysteine-lowering, but does not modulate markers of inflammation.
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Effect of cyclooxygenase-2 inhibition with rofecoxib on endothelial dysfunction and inflammatory markers in patients with coronary artery disease.

TL;DR: The addition of selective COX-2 inhibition with rofecoxib did not appear to have any favorable or adverse effects on endothelial dysfunction or vascular inflammation in patients with CAD using concomitant low-dose aspirin.