K
Karen Howie
Researcher at McMaster University
Publications - 49
Citations - 1541
Karen Howie is an academic researcher from McMaster University. The author has contributed to research in topics: Bone marrow & CD34. The author has an hindex of 18, co-authored 43 publications receiving 1405 citations. Previous affiliations of Karen Howie include St. Joseph Hospital & University of British Columbia.
Papers
More filters
Journal ArticleDOI
Effects of interleukin-13 blockade on allergen-induced airway responses in mild atopic asthma
Gail M. Gauvreau,Louis-Philippe Boulet,Donald W. Cockcroft,J. Mark FitzGerald,Christopher Carlsten,Beth E. Davis,Francine Deschesnes,MyLinh Duong,Billie Durn,Karen Howie,Linda Hui,Marion T. Kasaian,Kieran J. Killian,Tara X. Strinich,Richard M. Watson,Y. Nathalie,Simon Zhou,Donald G. Raible,Paul M. O'Byrne +18 more
TL;DR: IL-13 has a role in allergen-induced airway responses in humans and further study is required to determine whether anti- IL-13 monoclonal antibodies will be beneficial clinically.
Journal ArticleDOI
CD34+ hemopoietic progenitor cells are potent effectors of allergic inflammation.
Zoulfia Allakhverdi,Michael R. Comeau,Dirk E. Smith,Dean Toy,Leandra Mfuna Endam,Martin Desrosiers,Yong-Jun Liu,Karen Howie,Judah A. Denburg,Gail M. Gauvreau,Guy Delespesse +10 more
TL;DR: Blood CD34(+) cells, in addition to being progenitors, may act as proinflammatory effector cells by themselves and directly contribute to the allergic inflammation.
Journal ArticleDOI
Increased levels of CD34+ hemopoietic progenitor cells in atopic subjects.
TL;DR: Data indicate that flow cytometric estimation of CD34+ cells is predictive of the colony-forming capacity of the sample and may be a useful alternative tool to clonogenic assays for enumerating progenitors.
Journal ArticleDOI
Antisense therapy against CCR3 and the common beta chain attenuates allergen-induced eosinophilic responses.
Gail M. Gauvreau,Louis-Philippe Boulet,Donald W. Cockcroft,Adrian J Baatjes,Johanne Côté,Francine Deschesnes,Beth E. Davis,Tara X. Strinich,Karen Howie,MyLinh Duong,Richard M. Watson,Paolo M. Renzi,Paul M. O'Byrne +12 more
TL;DR: TPI ASM8 attenuates the allergen-induced increase in target gene mRNA and airway responses in subjects with mild asthma.
Journal ArticleDOI
Allergen-induced murine upper airway inflammation: local and systemic changes in murine experimental allergic rhinitis
Hiroko Saito,Karen Howie,Jennifer Wattie,Avram Denburg,Russ Ellis,Mark D. Inman,Judah A. Denburg +6 more
TL;DR: In this murine model of allergic rhinitis, haemopoietic progenitors are upregulated, which is consistent with the involvement of bone marrow in the pathogenesis of nasal mucosal inflammation.